Abstract
The optimum dose rates of betamethasone, dexamethasone (sodium phosphate) and methylprednisolone (acetate salt) were determined for the treatment of inflammatory pain in domestic fowl using the microcrystalline sodium urate model of articular pain. The response criteria were the changes in behavioural profiles and pain-related activity over 60 minutes commencing 1 hour after an intra-articular injection of sodium urate and a course of intramuscular injections of a range of doses of each drug on the previous 2 days. The optimum dose rates for betamethasone, dexamethasone and methylprednisolone respectively were 0.04, 0.06 and 2 mg kg(-1)and are in the range of the recommended doses for these drugs in mammals.
Original language | English |
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Pages (from-to) | 161-6 |
Number of pages | 6 |
Journal | Research in Veterinary Science |
Volume | 71 |
Issue number | 3 |
DOIs | |
Publication status | Published - Dec 2001 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Anti-Inflammatory Agents
- Behavior, Animal/drug effects
- Betamethasone
- Chickens
- Dexamethasone
- Dose-Response Relationship, Drug
- Inflammation
- Injections, Intra-Articular/veterinary
- Injections, Intramuscular/veterinary
- Male
- Methylprednisolone
- Pain
- Poultry Diseases
- Random Allocation