TY - JOUR
T1 - Effects of apolipoprotein E genotype on serum lipids in obstructive sleep apnoea
AU - Tisko, Radovan
AU - Sopkova, Zuzana
AU - Habalova, Viera
AU - Dorkova, Zuzana
AU - Slaba, Eva
AU - Javorsky, Martin
AU - Tkac, Ivan
AU - Riha, Renata L.
AU - Tkacova, Ruzena
PY - 2014/4/1
Y1 - 2014/4/1
N2 - There is increasing evidence that intermittent hypoxia resulting from obstructive sleep apnoea (OSA) is independently associated with dyslipidaemia. Currently, no data exist on potential links between OSA-related dyslipidaemia and susceptibility genes for dyslipidaemia in such patients. Our aim was to study the effects of the apolipoprotein E (APOE) genotype and sleep apnoea severity on atherogenic dyslipidaemia in patients with OSA. 519 clinically stable subjects prospectively recruited at a tertiary referral teaching hospital underwent full polysomnography. APOE gene polymorphisms were assessed using real-time PCR. In all APOE genotype groups, serum triglycerides increased while high-density lipoprotein (HDL) cholesterol was reduced with increasing severity of OSA in each APOE genotype group, whereas the deleterious effects of OSA on serum apolipoprotein (Apo)B levels were observed in ε2 carriers and the ε3/ε3 genotype only. Nevertheless, the ε4 allele carriers had ApoB levels within the risk range, irrespective of nocturnal hypoxia. In addition, among patients with the high-risk ε4 genotype, those with the most severe nocturnal hypoxia had significantly higher triglyceride and lower HDL cholesterol levels compared with nonhypoxic ε4 subjects. APOE genotype and the oxygen desaturation index were both independent predictors of serum triglyceride levels (p=0.009 and p<0.001, respectively; R2=0.148) and ApoB levels (p=0.001 and p=0.003, respectively; R2=0.104). Our findings suggest that OSA has adverse effects on several lipid parameters over and above the effects carried by APOE genotype. Further studies are needed to analyse the effects of high-risk genotypes on metabolic and cardiovascular outcomes in patients with OSA.
AB - There is increasing evidence that intermittent hypoxia resulting from obstructive sleep apnoea (OSA) is independently associated with dyslipidaemia. Currently, no data exist on potential links between OSA-related dyslipidaemia and susceptibility genes for dyslipidaemia in such patients. Our aim was to study the effects of the apolipoprotein E (APOE) genotype and sleep apnoea severity on atherogenic dyslipidaemia in patients with OSA. 519 clinically stable subjects prospectively recruited at a tertiary referral teaching hospital underwent full polysomnography. APOE gene polymorphisms were assessed using real-time PCR. In all APOE genotype groups, serum triglycerides increased while high-density lipoprotein (HDL) cholesterol was reduced with increasing severity of OSA in each APOE genotype group, whereas the deleterious effects of OSA on serum apolipoprotein (Apo)B levels were observed in ε2 carriers and the ε3/ε3 genotype only. Nevertheless, the ε4 allele carriers had ApoB levels within the risk range, irrespective of nocturnal hypoxia. In addition, among patients with the high-risk ε4 genotype, those with the most severe nocturnal hypoxia had significantly higher triglyceride and lower HDL cholesterol levels compared with nonhypoxic ε4 subjects. APOE genotype and the oxygen desaturation index were both independent predictors of serum triglyceride levels (p=0.009 and p<0.001, respectively; R2=0.148) and ApoB levels (p=0.001 and p=0.003, respectively; R2=0.104). Our findings suggest that OSA has adverse effects on several lipid parameters over and above the effects carried by APOE genotype. Further studies are needed to analyse the effects of high-risk genotypes on metabolic and cardiovascular outcomes in patients with OSA.
UR - http://www.scopus.com/inward/record.url?scp=84897386695&partnerID=8YFLogxK
U2 - 10.1183/09031936.00098513
DO - 10.1183/09031936.00098513
M3 - Article
C2 - 24232699
AN - SCOPUS:84897386695
SN - 0903-1936
VL - 43
SP - 1097
EP - 1105
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 4
ER -