Effects of bursty protein production on the noisy oscillatory properties of downstream pathways

D. L. K. Toner, R. Grima*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Experiments show that proteins are translated in sharp bursts; similar bursty phenomena have been observed for protein import into compartments. Here we investigate the effect of burstiness in protein expression and import on the stochastic properties of downstream pathways. We consider two identical pathways with equal mean input rates, except in one pathway proteins are input one at a time and in the other proteins are input in bursts. Deterministically the dynamics of these two pathways are indistinguishable. However the stochastic behavior falls in three categories: (i) both pathways display or do not display noise-induced oscillations; (ii) the non-bursty input pathway displays noise-induced oscillations whereas the bursty one does not; (iii) the reverse of (ii). We derive necessary conditions for these three cases to classify systems involving autocatalysis, trimerization and genetic feedback loops. Our results suggest that single cell rhythms can be controlled by regulation of burstiness in protein production.

Original languageEnglish
Article number2438
Number of pages13
JournalScientific Reports
Volume3
DOIs
Publication statusPublished - 14 Aug 2013

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