Effects of creatine supplementation on cerebral white matter in competitive sportsmen

Iain D Wilkinson; Nigel Mitchel; Simon Breivik; Pamela Greenwood; Paul D Griffiths; Edward M Winter; Edwin J R Van Beek

Effects of creatine supplementation on cerebral white matter in competitive sportsmen

Iain D Wilkinson, Nigel Mitchel, Simon Breivik, Pamela Greenwood, Paul D Griffiths, Edward M Winter, Edwin J R Van Beek

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: To determine the neurobiochemical sequelae of oral creatine monohydrate supplementation in active athletes.

DESIGN/PARTICIPANTS: Eighteen sportsmen underwent single-voxel proton magnetic resonance spectroscopy of the deep frontal cerebral white matter before and after 5 days of oral ingestion: 12 of 18 swallowed 4 x 5 g creatine monohydrate per day, and the remaining swallowed a placebo.

MAIN OUTCOME MEASUREMENTS: Creatine, choline, and N-acetyl spectral resonances were evaluated at both long (135 ms) and short (20 ms) echo times.

RESULTS: A mixed-design factorial ANOVA demonstrated no interaction over time in any of the measures (P at least 0.081).

CONCLUSIONS: The results suggest that, for the given dosage regimen, ingested creatine augmentation does not alter the magnetic resonance visible creatine pool in the deep frontal cerebral white matter of young active sportsmen.

Original language	English
Pages (from-to)	63-7
Number of pages	5
Journal	Clinical Journal of Sport Medicine
Volume	16
Issue number	1
Publication status	Published - Jan 2006

Keywords / Materials (for Non-textual outputs)

Administration, Oral
Adult
Brain Chemistry
Creatine
Double-Blind Method
Humans
Magnetic Resonance Spectroscopy
Male
Placebos
Sports

Cite this

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title = "Effects of creatine supplementation on cerebral white matter in competitive sportsmen",

abstract = "OBJECTIVES: To determine the neurobiochemical sequelae of oral creatine monohydrate supplementation in active athletes.DESIGN/PARTICIPANTS: Eighteen sportsmen underwent single-voxel proton magnetic resonance spectroscopy of the deep frontal cerebral white matter before and after 5 days of oral ingestion: 12 of 18 swallowed 4 x 5 g creatine monohydrate per day, and the remaining swallowed a placebo.MAIN OUTCOME MEASUREMENTS: Creatine, choline, and N-acetyl spectral resonances were evaluated at both long (135 ms) and short (20 ms) echo times.RESULTS: A mixed-design factorial ANOVA demonstrated no interaction over time in any of the measures (P at least 0.081).CONCLUSIONS: The results suggest that, for the given dosage regimen, ingested creatine augmentation does not alter the magnetic resonance visible creatine pool in the deep frontal cerebral white matter of young active sportsmen.",

keywords = "Administration, Oral, Adult, Brain Chemistry, Creatine, Double-Blind Method, Humans, Magnetic Resonance Spectroscopy, Male, Placebos, Sports",

author = "Wilkinson, {Iain D} and Nigel Mitchel and Simon Breivik and Pamela Greenwood and Griffiths, {Paul D} and Winter, {Edward M} and {Van Beek}, {Edwin J R}",

year = "2006",

month = jan,

language = "English",

volume = "16",

pages = "63--7",

journal = "Clinical Journal of Sport Medicine",

issn = "1050-642X",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - Effects of creatine supplementation on cerebral white matter in competitive sportsmen

AU - Wilkinson, Iain D

AU - Mitchel, Nigel

AU - Breivik, Simon

AU - Greenwood, Pamela

AU - Griffiths, Paul D

AU - Winter, Edward M

AU - Van Beek, Edwin J R

PY - 2006/1

Y1 - 2006/1

N2 - OBJECTIVES: To determine the neurobiochemical sequelae of oral creatine monohydrate supplementation in active athletes.DESIGN/PARTICIPANTS: Eighteen sportsmen underwent single-voxel proton magnetic resonance spectroscopy of the deep frontal cerebral white matter before and after 5 days of oral ingestion: 12 of 18 swallowed 4 x 5 g creatine monohydrate per day, and the remaining swallowed a placebo.MAIN OUTCOME MEASUREMENTS: Creatine, choline, and N-acetyl spectral resonances were evaluated at both long (135 ms) and short (20 ms) echo times.RESULTS: A mixed-design factorial ANOVA demonstrated no interaction over time in any of the measures (P at least 0.081).CONCLUSIONS: The results suggest that, for the given dosage regimen, ingested creatine augmentation does not alter the magnetic resonance visible creatine pool in the deep frontal cerebral white matter of young active sportsmen.

AB - OBJECTIVES: To determine the neurobiochemical sequelae of oral creatine monohydrate supplementation in active athletes.DESIGN/PARTICIPANTS: Eighteen sportsmen underwent single-voxel proton magnetic resonance spectroscopy of the deep frontal cerebral white matter before and after 5 days of oral ingestion: 12 of 18 swallowed 4 x 5 g creatine monohydrate per day, and the remaining swallowed a placebo.MAIN OUTCOME MEASUREMENTS: Creatine, choline, and N-acetyl spectral resonances were evaluated at both long (135 ms) and short (20 ms) echo times.RESULTS: A mixed-design factorial ANOVA demonstrated no interaction over time in any of the measures (P at least 0.081).CONCLUSIONS: The results suggest that, for the given dosage regimen, ingested creatine augmentation does not alter the magnetic resonance visible creatine pool in the deep frontal cerebral white matter of young active sportsmen.

KW - Administration, Oral

KW - Adult

KW - Brain Chemistry

KW - Creatine

KW - Double-Blind Method

KW - Humans

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Placebos

KW - Sports

M3 - Article

C2 - 16377978

SN - 1050-642X

VL - 16

SP - 63

EP - 67

JO - Clinical Journal of Sport Medicine

JF - Clinical Journal of Sport Medicine

IS - 1

ER -

Effects of creatine supplementation on cerebral white matter in competitive sportsmen

Abstract

Keywords / Materials (for Non-textual outputs)

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