Effects of Gefitinib, an Epidermal Growth Factor Receptor Inhibitor, on Human Placental Cell Growth

Ulrika W Nilsson; Terrance G Johns; Tania Wilmann; Tu'uhevaha Kaitu'u-Lino; Clare Whitehead; Eva Dimitriadis; Ellen Menkhorst; Burcu Saglam; Yane Gao; Sameer A Greenall; Andrew W Horne; Stephen Tong

doi:10.1097/AOG.0b013e3182a1ba56

Effects of Gefitinib, an Epidermal Growth Factor Receptor Inhibitor, on Human Placental Cell Growth

Ulrika W Nilsson, Terrance G Johns, Tania Wilmann, Tu'uhevaha Kaitu'u-Lino, Clare Whitehead, Eva Dimitriadis, Ellen Menkhorst, Burcu Saglam, Yane Gao, Sameer A Greenall, Andrew W Horne, Stephen Tong

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Placenta has the highest expression of epidermal growth factor (EGF) receptor of all tissues, a cell signaling pathway promoting survival and growth. Therefore, EGF receptor inhibition could potentially treat ectopic pregnancy. We undertook preclinical studies to examine whether gefitinib (orally available EGF receptor inhibitor) with or without methotrexate inhibits placental cell growth.

Original language	English
Pages (from-to)	737-744
Number of pages	8
Journal	Clinical obstetrics and gynecology
Volume	122
Issue number	4
DOIs	https://doi.org/10.1097/AOG.0b013e3182a1ba56
Publication status	Published - Oct 2013

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Nilsson, U. W., Johns, T. G., Wilmann, T., Kaitu'u-Lino, T., Whitehead, C., Dimitriadis, E., Menkhorst, E., Saglam, B., Gao, Y., Greenall, S. A., Horne, A. W., & Tong, S. (2013). Effects of Gefitinib, an Epidermal Growth Factor Receptor Inhibitor, on Human Placental Cell Growth. Clinical obstetrics and gynecology, 122(4), 737-744. https://doi.org/10.1097/AOG.0b013e3182a1ba56

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abstract = "Placenta has the highest expression of epidermal growth factor (EGF) receptor of all tissues, a cell signaling pathway promoting survival and growth. Therefore, EGF receptor inhibition could potentially treat ectopic pregnancy. We undertook preclinical studies to examine whether gefitinib (orally available EGF receptor inhibitor) with or without methotrexate inhibits placental cell growth.",

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AU - Nilsson, Ulrika W

AU - Johns, Terrance G

AU - Wilmann, Tania

AU - Kaitu'u-Lino, Tu'uhevaha

AU - Whitehead, Clare

AU - Dimitriadis, Eva

AU - Menkhorst, Ellen

AU - Saglam, Burcu

AU - Gao, Yane

AU - Greenall, Sameer A

AU - Horne, Andrew W

AU - Tong, Stephen

PY - 2013/10

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N2 - Placenta has the highest expression of epidermal growth factor (EGF) receptor of all tissues, a cell signaling pathway promoting survival and growth. Therefore, EGF receptor inhibition could potentially treat ectopic pregnancy. We undertook preclinical studies to examine whether gefitinib (orally available EGF receptor inhibitor) with or without methotrexate inhibits placental cell growth.

AB - Placenta has the highest expression of epidermal growth factor (EGF) receptor of all tissues, a cell signaling pathway promoting survival and growth. Therefore, EGF receptor inhibition could potentially treat ectopic pregnancy. We undertook preclinical studies to examine whether gefitinib (orally available EGF receptor inhibitor) with or without methotrexate inhibits placental cell growth.

U2 - 10.1097/AOG.0b013e3182a1ba56

DO - 10.1097/AOG.0b013e3182a1ba56

M3 - Article

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SN - 0009-9201

VL - 122

SP - 737

EP - 744

JO - Clinical obstetrics and gynecology

JF - Clinical obstetrics and gynecology

IS - 4

ER -

Effects of Gefitinib, an Epidermal Growth Factor Receptor Inhibitor, on Human Placental Cell Growth

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