Projects per year
Testosterone increased mesotocin mRNA expression in both the PVN and BnST, but neither oestradiol or progesterone had any significant effect on expression. We also quantified mesotocin protein levels using immunohistochemistry, but there was no observable difference between treatments in staining intensity. Mesotocin receptors are primarily located in the lateral septum (LS) in the chicken. In this study we found no significant effect of steroid treatment on mestotocin receptors in the LS using receptor autoradiography. For vasotocin, both testosterone and oestradiol increased mRNA expression in the BnST but not the PVN. Together these findings demonstrate for the first time that gonadal steroid hormones can upregulate the mesotocin and vasotocin systems in the brain of the domestic hen and that the effect of testosterone on mesotocin mRNA expression in the BnST is direct, and not via aromatisation into oestrogen; further studies using aromatase inhibitors could test this hypothesis.
Research supported by the BBSRC and the British Society for Neuroendocrinology.
|Publication status||Published - 2016|
|Event||Edinburgh Neuroscience day - Edinburgh, United Kingdom|
Duration: 30 Mar 2016 → …
|Conference||Edinburgh Neuroscience day|
|Period||30/03/16 → …|
15/06/15 → 24/07/15
Burdon, T., Argyle, D., Ashworth, C., Beard, P., Brunton, P., Burt, D., Clinton, M., Dunn, I., Farquharson, C., Headon, D., Hocking, P., Hohenstein, P., Hume, D., Jackson, I., McColl, B., McGrew, M., McLachlan, G., Sang, H., Summers, K. & Whitelaw, B.
1/04/12 → 31/03/17