Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men

Deborah J Wake, Roland H Stimson, Garry D Tan, Natalie Z M Homer, Ruth Andrew, Fredrik Karpe, Brian R Walker

Research output: Contribution to journalArticlepeer-review

Abstract

In animals, peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARgamma agonists down-regulate 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mRNA and activity in liver and adipose tissue, respectively, and PPARgamma agonists reduce ACTH secretion from corticotrope cells.
Original languageEnglish
Pages (from-to)1848-56
Number of pages9
JournalJournal of Clinical Endocrinology & Metabolism
Volume92
Issue number5
DOIs
Publication statusPublished - Feb 2007

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