Effects of sex and age on regional prefrontal brain volume in two human cohorts

Patricia E. Cowell; Vanessa A. Sluming; Iain D. Wilkinson; Enis Cezayirli; Charles A. J. Romanowski; Jocasta A. Webb; Simon S. Keller; Andrew Mayes; Neil Roberts

doi:10.1111/j.1460-9568.2006.05281.x

Effects of sex and age on regional prefrontal brain volume in two human cohorts

Patricia E. Cowell^*, Vanessa A. Sluming, Iain D. Wilkinson, Enis Cezayirli, Charles A. J. Romanowski, Jocasta A. Webb, Simon S. Keller, Andrew Mayes, Neil Roberts

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

This study examined interactive effects of sex and age on prefrontal brain anatomy in humans. It specifically targeted ranges of the adult life span and regions of cortex that previously showed male-female differences. Participants were 68 healthy human males and females aged 20-72 years. Data collection and analysis were conducted in parallel across two cohorts (laboratories) to investigate reproducibility of effects in relation to sex and age. Volumes for four regional prefrontal subfields per hemisphere were obtained from high-resolution MRI. Regional sex by age interactions were replicated across cohorts. In men, age effects were greatest in medial prefrontal volume, with decreases in dorsal medial and orbital medial regions. In women, age-related changes in medial prefrontal regions were limited to the dorsal volume, with additional decreases observed in lateral subfields. Cohort and Cohort x Age effects in total brain and total prefrontal volume were linked to a combination of methodological and sampling-related factors. Findings indicated that neuroanatomical changes throughout adulthood unfold along different time scales in men and women. Results also showed that sex differences in ageing localized to medial prefrontal regions were particularly robust to variation across cohorts.

Original language	English
Pages (from-to)	307-318
Number of pages	12
Journal	European Journal of Neuroscience
Volume	25
Issue number	1
DOIs	https://doi.org/10.1111/j.1460-9568.2006.05281.x
Publication status	Published - Jan 2007

Keywords / Materials (for Non-textual outputs)

Cavalieri method
cerebral cortex
healthy adults
MRI
stereology
VOXEL-BASED MORPHOMETRY
GRAY-MATTER DENSITY
POSITRON-EMISSION-TOMOGRAPHY
CEREBRAL-CORTEX
HEALTHY-ADULTS
IN-VIVO
INDIVIDUAL-DIFFERENCES
FLUID INTELLIGENCE
CORTICAL FUNCTION
DECISION-MAKING

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title = "Effects of sex and age on regional prefrontal brain volume in two human cohorts",

abstract = "This study examined interactive effects of sex and age on prefrontal brain anatomy in humans. It specifically targeted ranges of the adult life span and regions of cortex that previously showed male-female differences. Participants were 68 healthy human males and females aged 20-72 years. Data collection and analysis were conducted in parallel across two cohorts (laboratories) to investigate reproducibility of effects in relation to sex and age. Volumes for four regional prefrontal subfields per hemisphere were obtained from high-resolution MRI. Regional sex by age interactions were replicated across cohorts. In men, age effects were greatest in medial prefrontal volume, with decreases in dorsal medial and orbital medial regions. In women, age-related changes in medial prefrontal regions were limited to the dorsal volume, with additional decreases observed in lateral subfields. Cohort and Cohort x Age effects in total brain and total prefrontal volume were linked to a combination of methodological and sampling-related factors. Findings indicated that neuroanatomical changes throughout adulthood unfold along different time scales in men and women. Results also showed that sex differences in ageing localized to medial prefrontal regions were particularly robust to variation across cohorts.",

keywords = "Cavalieri method, cerebral cortex, healthy adults, MRI, stereology, VOXEL-BASED MORPHOMETRY, GRAY-MATTER DENSITY, POSITRON-EMISSION-TOMOGRAPHY, CEREBRAL-CORTEX, HEALTHY-ADULTS, IN-VIVO, INDIVIDUAL-DIFFERENCES, FLUID INTELLIGENCE, CORTICAL FUNCTION, DECISION-MAKING",

author = "Cowell, {Patricia E.} and Sluming, {Vanessa A.} and Wilkinson, {Iain D.} and Enis Cezayirli and Romanowski, {Charles A. J.} and Webb, {Jocasta A.} and Keller, {Simon S.} and Andrew Mayes and Neil Roberts",

year = "2007",

month = jan,

doi = "10.1111/j.1460-9568.2006.05281.x",

language = "English",

volume = "25",

pages = "307--318",

journal = "European Journal of Neuroscience",

issn = "0953-816X",

publisher = "Wiley-Blackwell",

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AU - Cowell, Patricia E.

AU - Sluming, Vanessa A.

AU - Wilkinson, Iain D.

AU - Cezayirli, Enis

AU - Romanowski, Charles A. J.

AU - Webb, Jocasta A.

AU - Keller, Simon S.

AU - Mayes, Andrew

AU - Roberts, Neil

PY - 2007/1

Y1 - 2007/1

N2 - This study examined interactive effects of sex and age on prefrontal brain anatomy in humans. It specifically targeted ranges of the adult life span and regions of cortex that previously showed male-female differences. Participants were 68 healthy human males and females aged 20-72 years. Data collection and analysis were conducted in parallel across two cohorts (laboratories) to investigate reproducibility of effects in relation to sex and age. Volumes for four regional prefrontal subfields per hemisphere were obtained from high-resolution MRI. Regional sex by age interactions were replicated across cohorts. In men, age effects were greatest in medial prefrontal volume, with decreases in dorsal medial and orbital medial regions. In women, age-related changes in medial prefrontal regions were limited to the dorsal volume, with additional decreases observed in lateral subfields. Cohort and Cohort x Age effects in total brain and total prefrontal volume were linked to a combination of methodological and sampling-related factors. Findings indicated that neuroanatomical changes throughout adulthood unfold along different time scales in men and women. Results also showed that sex differences in ageing localized to medial prefrontal regions were particularly robust to variation across cohorts.

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KW - stereology

KW - VOXEL-BASED MORPHOMETRY

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KW - POSITRON-EMISSION-TOMOGRAPHY

KW - CEREBRAL-CORTEX

KW - HEALTHY-ADULTS

KW - IN-VIVO

KW - INDIVIDUAL-DIFFERENCES

KW - FLUID INTELLIGENCE

KW - CORTICAL FUNCTION

KW - DECISION-MAKING

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DO - 10.1111/j.1460-9568.2006.05281.x

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JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

IS - 1

ER -

Effects of sex and age on regional prefrontal brain volume in two human cohorts

Abstract

Keywords / Materials (for Non-textual outputs)

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