Effects of surgery on free and total 25 hydroxyvitamin D concentrations in dogs

Dylan N Clements; Gemma Bruce; John M Ryan; Ian G Handel; Ioannis L Oikonomidis; Adam G Gow; Helen Evans; Susan Campbell; Emma Hurst; Richard J Mellanby

doi:10.1111/jvim.15933

Effects of surgery on free and total 25 hydroxyvitamin D concentrations in dogs

Dylan N Clements, Gemma Bruce, John M Ryan, Ian G Handel, Ioannis L Oikonomidis, Adam G Gow, Helen Evans, Susan Campbell, Emma Hurst, Richard J Mellanby

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

BACKGROUND: It is unclear whether a low total 25(OH)D concentration is a cause or consequence of illnesses. To address this knowledge gap, studies measuring free and total 25(OH)D during the evolution and resolution of an inflammatory process are required.

OBJECTIVES: Serum total and free 25(OH)D concentrations would transiently decline after cruciate surgery in dogs.

ANIMALS: Seventeen client-owned dogs with a spontaneous cranial cruciate ligament rupture (CCLR).

METHODS: A longitudinal cohort study involving the measurement of serum concentrations of total and free 25(OH)D, total calcium, creatinine, albumin, phosphate, C-reactive protein and plasma ionized calcium, at 1 day before and a median time of 1 and 60 days after surgical treatment of CCLR.

RESULTS: Median serum concentrations of total 25(OH)D before surgery (80.3 nmoL/L [range, 43.5-137.3]) significantly declined immediately after surgery; (64.8 nmoL/L [range, 36.3-116.5] 1 day after surgery, P < .005) before increasing to become nonsignificantly different from concentrations before surgery at day 60 after surgery (median 78.0 nmoL/L [range, 24.2-115.8], P = .14). In contrast, median free 25(OH)D concentrations before surgery (7.6 pg/mL [range, 3.8-12.2]) significantly increased immediately after surgery (9.2 pg/mL [range, 5.2-15.7], P < .05) before declining to become nonsignificantly different from before surgery concentrations at day 60 after surgery (median 6.2 pg/mL [range, 4.0-15.8], P = .37).

CONCLUSION AND CLINICAL IMPORTANCE: This study reveals the difficulties of assessing vitamin D status in dogs following elective surgery.

Original language	English
Pages (from-to)	2617- 2621
Journal	Journal of Veterinary Internal Medicine
Volume	34
Issue number	6
Early online date	14 Oct 2020
DOIs	https://doi.org/10.1111/jvim.15933
Publication status	E-pub ahead of print - 14 Oct 2020

Keywords / Materials (for Non-textual outputs)

25 hydroxyvitamin D
cruciate rupture
dog
inflammation
vitamin D

Access to Document

10.1111/jvim.15933

jvim.15933
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Final published version, 364 KBLicence: Creative Commons: Attribution (CC-BY)

John Ryan, MVB CertSAS Dipl.ECVS MRCVS FHEA RCVS & European Veterinary Specialist in Small Animal Surgery
- Royal (Dick) School of Veterinary Studies - Senior Lecturer in Small Animal Orthopaedics
Person: Academic: Research Active

Cite this

@article{74b13e1b442244cea8fe842c870e6373,

title = "Effects of surgery on free and total 25 hydroxyvitamin D concentrations in dogs",

abstract = "BACKGROUND: It is unclear whether a low total 25(OH)D concentration is a cause or consequence of illnesses. To address this knowledge gap, studies measuring free and total 25(OH)D during the evolution and resolution of an inflammatory process are required.OBJECTIVES: Serum total and free 25(OH)D concentrations would transiently decline after cruciate surgery in dogs.ANIMALS: Seventeen client-owned dogs with a spontaneous cranial cruciate ligament rupture (CCLR).METHODS: A longitudinal cohort study involving the measurement of serum concentrations of total and free 25(OH)D, total calcium, creatinine, albumin, phosphate, C-reactive protein and plasma ionized calcium, at 1 day before and a median time of 1 and 60 days after surgical treatment of CCLR.RESULTS: Median serum concentrations of total 25(OH)D before surgery (80.3 nmoL/L [range, 43.5-137.3]) significantly declined immediately after surgery; (64.8 nmoL/L [range, 36.3-116.5] 1 day after surgery, P < .005) before increasing to become nonsignificantly different from concentrations before surgery at day 60 after surgery (median 78.0 nmoL/L [range, 24.2-115.8], P = .14). In contrast, median free 25(OH)D concentrations before surgery (7.6 pg/mL [range, 3.8-12.2]) significantly increased immediately after surgery (9.2 pg/mL [range, 5.2-15.7], P < .05) before declining to become nonsignificantly different from before surgery concentrations at day 60 after surgery (median 6.2 pg/mL [range, 4.0-15.8], P = .37).CONCLUSION AND CLINICAL IMPORTANCE: This study reveals the difficulties of assessing vitamin D status in dogs following elective surgery.",

keywords = "25 hydroxyvitamin D, cruciate rupture, dog, inflammation, vitamin D",

author = "Clements, {Dylan N} and Gemma Bruce and Ryan, {John M} and Handel, {Ian G} and Oikonomidis, {Ioannis L} and Gow, {Adam G} and Helen Evans and Susan Campbell and Emma Hurst and Mellanby, {Richard J}",

note = "{\textcopyright} 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.",

year = "2020",

month = oct,

day = "14",

doi = "10.1111/jvim.15933",

language = "English",

volume = "34",

pages = "2617-- 2621",

journal = "Journal of Veterinary Internal Medicine",

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}

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T1 - Effects of surgery on free and total 25 hydroxyvitamin D concentrations in dogs

AU - Clements, Dylan N

AU - Bruce, Gemma

AU - Ryan, John M

AU - Handel, Ian G

AU - Oikonomidis, Ioannis L

AU - Gow, Adam G

AU - Evans, Helen

AU - Campbell, Susan

AU - Hurst, Emma

AU - Mellanby, Richard J

PY - 2020/10/14

Y1 - 2020/10/14

N2 - BACKGROUND: It is unclear whether a low total 25(OH)D concentration is a cause or consequence of illnesses. To address this knowledge gap, studies measuring free and total 25(OH)D during the evolution and resolution of an inflammatory process are required.OBJECTIVES: Serum total and free 25(OH)D concentrations would transiently decline after cruciate surgery in dogs.ANIMALS: Seventeen client-owned dogs with a spontaneous cranial cruciate ligament rupture (CCLR).METHODS: A longitudinal cohort study involving the measurement of serum concentrations of total and free 25(OH)D, total calcium, creatinine, albumin, phosphate, C-reactive protein and plasma ionized calcium, at 1 day before and a median time of 1 and 60 days after surgical treatment of CCLR.RESULTS: Median serum concentrations of total 25(OH)D before surgery (80.3 nmoL/L [range, 43.5-137.3]) significantly declined immediately after surgery; (64.8 nmoL/L [range, 36.3-116.5] 1 day after surgery, P < .005) before increasing to become nonsignificantly different from concentrations before surgery at day 60 after surgery (median 78.0 nmoL/L [range, 24.2-115.8], P = .14). In contrast, median free 25(OH)D concentrations before surgery (7.6 pg/mL [range, 3.8-12.2]) significantly increased immediately after surgery (9.2 pg/mL [range, 5.2-15.7], P < .05) before declining to become nonsignificantly different from before surgery concentrations at day 60 after surgery (median 6.2 pg/mL [range, 4.0-15.8], P = .37).CONCLUSION AND CLINICAL IMPORTANCE: This study reveals the difficulties of assessing vitamin D status in dogs following elective surgery.

AB - BACKGROUND: It is unclear whether a low total 25(OH)D concentration is a cause or consequence of illnesses. To address this knowledge gap, studies measuring free and total 25(OH)D during the evolution and resolution of an inflammatory process are required.OBJECTIVES: Serum total and free 25(OH)D concentrations would transiently decline after cruciate surgery in dogs.ANIMALS: Seventeen client-owned dogs with a spontaneous cranial cruciate ligament rupture (CCLR).METHODS: A longitudinal cohort study involving the measurement of serum concentrations of total and free 25(OH)D, total calcium, creatinine, albumin, phosphate, C-reactive protein and plasma ionized calcium, at 1 day before and a median time of 1 and 60 days after surgical treatment of CCLR.RESULTS: Median serum concentrations of total 25(OH)D before surgery (80.3 nmoL/L [range, 43.5-137.3]) significantly declined immediately after surgery; (64.8 nmoL/L [range, 36.3-116.5] 1 day after surgery, P < .005) before increasing to become nonsignificantly different from concentrations before surgery at day 60 after surgery (median 78.0 nmoL/L [range, 24.2-115.8], P = .14). In contrast, median free 25(OH)D concentrations before surgery (7.6 pg/mL [range, 3.8-12.2]) significantly increased immediately after surgery (9.2 pg/mL [range, 5.2-15.7], P < .05) before declining to become nonsignificantly different from before surgery concentrations at day 60 after surgery (median 6.2 pg/mL [range, 4.0-15.8], P = .37).CONCLUSION AND CLINICAL IMPORTANCE: This study reveals the difficulties of assessing vitamin D status in dogs following elective surgery.

KW - 25 hydroxyvitamin D

KW - cruciate rupture

KW - dog

KW - inflammation

KW - vitamin D

U2 - 10.1111/jvim.15933

DO - 10.1111/jvim.15933

M3 - Article

C2 - 33179819

SN - 0891-6640

VL - 34

SP - 2617

EP - 2621

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

IS - 6

ER -

Effects of surgery on free and total 25 hydroxyvitamin D concentrations in dogs

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Keywords / Materials (for Non-textual outputs)

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John Ryan, MVB CertSAS Dipl.ECVS MRCVS FHEA RCVS & European Veterinary Specialist in Small Animal Surgery

Cite this