Efficacy and complications of adalimumab treatment for medically-refractory Crohn's disease: analysis of nationwide experience in Scotland (2004-2008)

G. T. Ho, A. Mowat, L. Potts, A. Cahill, C. Mowat, C. W. Lees, N. C. Hare, J. A. Wilson, R. Boulton-Jones, M. Priest, D. A. Watts, A. G. Shand, I. D. Arnott, R. K. Russell, D. C. Wilson, A. J. Morris, J. Satsangi

Research output: Contribution to journalArticlepeer-review

Abstract

Background  Adalimumab is a second generation humanized anti-tumour necrosis factor (TNF) monoclonal antibody with established efficacy in Crohn’s disease (CD).

Aims  To evaluate the efficacy and safety of adalimumab on a nationwide clinical setting.

Methods  We used the Scottish Society of Gastroenterology network to identify and follow up the clinical outcomes of patients with CD treated with adalimumab over a 4-year period (2004–2008).

Results  A total of 98 patients received adalimumab - 100.5 patient follow-up years were recorded (64.3% females; median age at diagnosis of 20.7 years; 88.8% treated with 80/40 mg induction regimen. Eighty eight (89.8%) had previous infliximab with 29 (32.9%) primary nonresponders; 32 (32.6%) were corticosteroid-dependent; 47 (47.9%) were intolerant/resistant to most immunosuppressive therapies (two or more). In all, 60% of patients were in clinical remission at 1-year follow-up, with 30% and 55% requiring dose escalation to weekly therapy at 1-and 2-year follow-up respectively. Overall, 29 (29.6%) patients developed complications with eight nonfatal serious (8.2%) adverse events and 2 (2.0%) case fatalities (sepsis following perforation and disseminated colorectal cancer, respectively).

Conclusions  Adalimumab is efficacious in severe and refractory CD in the clinical setting, although there remain significant therapy- and disease-related risks of serious complications.

Original languageEnglish
Pages (from-to)527-534
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume29
Issue number5
DOIs
Publication statusPublished - 1 Mar 2009

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