Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial

William MacNee; Richard J Allan; Ieuan Jones; Maria Cristina De Salvo; Lisa F Tan

doi:10.1136/thoraxjnl-2012-202744

Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial

William MacNee, Richard J Allan, Ieuan Jones, Maria Cristina De Salvo, Lisa F Tan

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic obstructive pulmonary disease (COPD) is a common lung disease leading to progressive decline in lung function. Inhibition of release of inflammatory mediators by p38 inhibitors may be a useful treatment for chronic inflammation of the airways thought to underlie the pathogenesis of the disease.

Original language	English
Pages (from-to)	738-45
Number of pages	8
Journal	Thorax
Volume	68
Issue number	8
DOIs	https://doi.org/10.1136/thoraxjnl-2012-202744
Publication status	Published - Aug 2013

Keywords / Materials (for Non-textual outputs)

Administration, Oral
Adult
Aged
Aged, 80 and over
Benzamides
C-Reactive Protein
Dose-Response Relationship, Drug
Double-Blind Method
Female
Follow-Up Studies
Forced Expiratory Volume
Humans
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive
Pyridones
Retrospective Studies
Severity of Illness Index
Spirometry
Treatment Outcome
p38 Mitogen-Activated Protein Kinases

Access to Document

10.1136/thoraxjnl-2012-202744

http://thorax.bmj.com/content/68/8/738

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J. (Principal Investigator)
MRC
1/09/12 → 31/08/16
Project: Research

Cite this

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title = "Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial",

abstract = "Chronic obstructive pulmonary disease (COPD) is a common lung disease leading to progressive decline in lung function. Inhibition of release of inflammatory mediators by p38 inhibitors may be a useful treatment for chronic inflammation of the airways thought to underlie the pathogenesis of the disease.",

keywords = "Administration, Oral, Adult, Aged, Aged, 80 and over, Benzamides, C-Reactive Protein, Dose-Response Relationship, Drug, Double-Blind Method, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Pyridones, Retrospective Studies, Severity of Illness Index, Spirometry, Treatment Outcome, p38 Mitogen-Activated Protein Kinases",

author = "William MacNee and Allan, \{Richard J\} and Ieuan Jones and \{De Salvo\}, \{Maria Cristina\} and Tan, \{Lisa F\}",

year = "2013",

month = aug,

doi = "10.1136/thoraxjnl-2012-202744",

language = "English",

volume = "68",

pages = "738--45",

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T1 - Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease

T2 - a randomised clinical trial

AU - MacNee, William

AU - Allan, Richard J

AU - Jones, Ieuan

AU - De Salvo, Maria Cristina

AU - Tan, Lisa F

PY - 2013/8

Y1 - 2013/8

N2 - Chronic obstructive pulmonary disease (COPD) is a common lung disease leading to progressive decline in lung function. Inhibition of release of inflammatory mediators by p38 inhibitors may be a useful treatment for chronic inflammation of the airways thought to underlie the pathogenesis of the disease.

AB - Chronic obstructive pulmonary disease (COPD) is a common lung disease leading to progressive decline in lung function. Inhibition of release of inflammatory mediators by p38 inhibitors may be a useful treatment for chronic inflammation of the airways thought to underlie the pathogenesis of the disease.

KW - Administration, Oral

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Benzamides

KW - C-Reactive Protein

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Female

KW - Follow-Up Studies

KW - Forced Expiratory Volume

KW - Humans

KW - Male

KW - Middle Aged

KW - Pulmonary Disease, Chronic Obstructive

KW - Pyridones

KW - Retrospective Studies

KW - Severity of Illness Index

KW - Spirometry

KW - Treatment Outcome

KW - p38 Mitogen-Activated Protein Kinases

U2 - 10.1136/thoraxjnl-2012-202744

DO - 10.1136/thoraxjnl-2012-202744

M3 - Article

C2 - 23539534

SN - 0040-6376

VL - 68

SP - 738

EP - 745

JO - Thorax

JF - Thorax

IS - 8

ER -

Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial

Abstract

Keywords / Materials (for Non-textual outputs)

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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

Cite this