Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

Rong Ma, Yiping Wang, Li Yan, Lili Ma, Zhigang Wang, Hoi Ching Chan, Sung Kay Chiu, Xianfeng Chen, Guangyu Zhu

Research output: Contribution to journalArticlepeer-review

Abstract

A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(iv) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.

Original languageEnglish
Pages (from-to)7859-7862
Number of pages4
JournalChemical Communications
Volume51
Issue number37
DOIs
Publication statusPublished - 7 May 2015

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