Abstract / Description of output
A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(iv) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.
Original language | English |
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Pages (from-to) | 7859-7862 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 51 |
Issue number | 37 |
DOIs | |
Publication status | Published - 7 May 2015 |