Efficient organocatalytic α-sulfenylation of substituted piperazine-2,5-diones

Ramin Dubey, Nathan W. Polaske, Gary S. Nichol, Bogdan Olenyuk*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Organocatalytic α-sulfenylation of substituted piperazine-2,5-diones is reported through the use of cinchona alkaloids as Lewis bases and electrophilic sulfur transfer reagents. 1-Phenylsulfanyl[1,2,4]triazole, a novel sulfur transfer reagent, gave excellent product yields with a number of substituted piperazine-2,5-diones under mild conditions. Catalyst loading, stoichiometry of sulfur electrophile, temperature, and solvent were optimized to achieve high product yields.

Original languageEnglish
Pages (from-to)4310-4313
Number of pages4
JournalTetrahedron Letters
Issue number30
Publication statusPublished - 29 Jul 2009


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