Electric Fields Due to Synaptic Currents Sharpen Excitatory Transmission

Serigy Sylantyev, Leonid P Savtchenko, Yin-Ping Niu, Anton I Ivanov, Thomas P Jensen, Dimitri M Kullmann, Min-Yi Xiao, Dmitri A Rusakov

Research output: Contribution to journalArticlepeer-review

Abstract

The synaptic response waveform, which determines signal integration properties in the brain, depends on the spatiotemporal profile of neurotransmitter in the synaptic cleft. Here, we show that electrophoretic interactions between AMPA receptor-mediated excitatory currents and negatively charged glutamate molecules accelerate the clearance of glutamate from the synaptic cleft, speeding up synaptic responses. This phenomenon is reversed upon depolarization and diminished when intracleft electric fields are weakened through a decrease in the AMPA receptor density. In contrast, the kinetics of receptor-mediated currents evoked by direct application of glutamate are voltage-independent, as are synaptic currents mediated by the electrically neutral neurotransmitter GABA. Voltage-dependent temporal tuning of excitatory synaptic responses may thus contribute to signal integration in neural circuits.
Original languageEnglish
Pages (from-to)1845-1849
Number of pages5
JournalScience
Volume319
Issue number5871
DOIs
Publication statusPublished - 28 Mar 2008

Keywords

  • Animals
  • Cells, Cultured
  • Dendrites
  • Diffusion
  • Dipeptides
  • Excitatory Postsynaptic Potentials
  • Glutamic Acid
  • Magnesium
  • Male
  • Monte Carlo Method
  • Patch-Clamp Techniques
  • Pyramidal Cells
  • Quinoxalines
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, AMPA
  • Receptors, GABA
  • Synapses
  • gamma-Aminobutyric Acid

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