Electrodrugs: an electrochemical prodrug activation strategy

Daniel J. Norman, Eva González-Fernández, Jessica Clavadetscher, Lulu Tucker, Matteo Staderini, Andrew R. Mount, Alan F. Murray, Mark Bradley

Research output: Contribution to journalArticlepeer-review

Abstract

The term electroceutical has been used to describe implanted devices that deliver electrical stimuli to modify biological function. Herein, we describe a new concept in electroceuticals, demonstrating for the first time the electrochemical activation of metal-based prodrugs. This is illustrated by the controlled activation of Pt(IV) prodrugs into their active Pt(II) forms within a cellular context allowing selectivity and control of where, when and how much active drug is generated.

Original languageEnglish
Pages (from-to)9242-9245
Number of pages4
JournalChemical Communications
Volume54
Issue number66
Early online date24 Jul 2018
DOIs
Publication statusE-pub ahead of print - 24 Jul 2018

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