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The term electroceutical has been used to describe implanted devices that deliver electrical stimuli to modify biological function. Herein, we describe a new concept in electroceuticals, demonstrating for the first time the electrochemical activation of metal-based prodrugs. This is illustrated by the controlled activation of Pt(IV) prodrugs into their active Pt(II) forms within a cellular context allowing selectivity and control of where, when and how much active drug is generated.
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Norman, D. (Creator), González-Fernández, E. (Creator), Clavadetscher, J. (Creator), Tucker, L. (Creator), Staderini, M. (Creator), Mount, A. (Creator), Murray, A. (Creator) & Bradley, M. (Creator), Edinburgh DataShare, 27 Jul 2018