Projects per year
Herein we report the preparation of BODIPY mesoionic acid fluorides through a short sequence involving an isocyanide multicomponent reaction as the key synthetic step. These novel BODIPY acid fluorides are water-stable electrophilic reagents that can be used for the fluorescent derivatization of amine-containing biomolecules using mild and activation-free reaction conditions. As a proof of principle, we have labeled the antifungal natamycin and generated a novel fluorogenic probe for imaging a variety of human and plant fungal pathogens, with excellent selectivity over bacterial cells.
FingerprintDive into the research topics of 'Electrophilic, Activation-Free Fluorogenic Reagent for Labeling Bioactive Amines'. Together they form a unique fingerprint.
- 2 Finished
1/09/15 → 30/06/19
1/08/13 → 31/07/17