Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome

GAIN Int Steering Comm Investigato; S Aslanyan; CJ Weir; KR Lees

doi:10.1161/01.STR.0000126598.88662.16

Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome

GAIN Int Steering Comm Investigato, S Aslanyan^*, CJ Weir, KR Lees

^*Corresponding author for this work

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Background-It is controversial which component of blood pressure (BP) during acute period of stroke best predicts outcome. We hypothesized that elevated pulse pressure (PP), the difference between systolic BP (SBP) and diastolic BP (DBP), is independently associated with poor stroke outcome at 3 months.

Methods-We analyzed both treatment groups from the Glycine Antagonist (Gavestinel) in Neuroprotection (GAIN) International trial (1455 ischemic stroke cases of mostly moderate severity). Cox proportional hazards and logistic regression modeling corrected for demography, medical history, heart rate, stroke severity, and clinical subtype.

Results-Elevated weighted average PP during the first 60 hours was associated with poor outcome by mortality, Barthel index, National Institutes of Health Stroke Score (NIHSS) and Rankin scores. Elevated baseline PP was associated with Barthel index and Rankin score.

Conclusion-Elevated PP is associated with poor stroke outcome at 3 months.

Original language	English
Pages (from-to)	E153-E155
Number of pages	3
Journal	Stroke
Volume	35
Issue number	6
DOIs	https://doi.org/10.1161/01.STR.0000126598.88662.16
Publication status	Published - Jun 2004

Keywords / Materials (for Non-textual outputs)

ischemia
stroke
outcome
BLOOD-PRESSURE
TRIAL

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10.1161/01.STR.0000126598.88662.16

Cite this

@article{48ab125d5c184bfe86b8cd46eaf68058,

title = "Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome",

abstract = "Background-It is controversial which component of blood pressure (BP) during acute period of stroke best predicts outcome. We hypothesized that elevated pulse pressure (PP), the difference between systolic BP (SBP) and diastolic BP (DBP), is independently associated with poor stroke outcome at 3 months.Methods-We analyzed both treatment groups from the Glycine Antagonist (Gavestinel) in Neuroprotection (GAIN) International trial (1455 ischemic stroke cases of mostly moderate severity). Cox proportional hazards and logistic regression modeling corrected for demography, medical history, heart rate, stroke severity, and clinical subtype.Results-Elevated weighted average PP during the first 60 hours was associated with poor outcome by mortality, Barthel index, National Institutes of Health Stroke Score (NIHSS) and Rankin scores. Elevated baseline PP was associated with Barthel index and Rankin score.Conclusion-Elevated PP is associated with poor stroke outcome at 3 months.",

keywords = "ischemia, stroke, outcome, BLOOD-PRESSURE, TRIAL",

author = "{GAIN Int Steering Comm Investigato} and S Aslanyan and CJ Weir and KR Lees",

year = "2004",

month = jun,

doi = "10.1161/01.STR.0000126598.88662.16",

language = "English",

volume = "35",

pages = "E153--E155",

journal = "Stroke",

issn = "0039-2499",

publisher = "Lippincott Williams & Wilkins",

number = "6",

}

TY - JOUR

T1 - Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome

AU - GAIN Int Steering Comm Investigato

AU - Aslanyan, S

AU - Weir, CJ

AU - Lees, KR

PY - 2004/6

Y1 - 2004/6

N2 - Background-It is controversial which component of blood pressure (BP) during acute period of stroke best predicts outcome. We hypothesized that elevated pulse pressure (PP), the difference between systolic BP (SBP) and diastolic BP (DBP), is independently associated with poor stroke outcome at 3 months.Methods-We analyzed both treatment groups from the Glycine Antagonist (Gavestinel) in Neuroprotection (GAIN) International trial (1455 ischemic stroke cases of mostly moderate severity). Cox proportional hazards and logistic regression modeling corrected for demography, medical history, heart rate, stroke severity, and clinical subtype.Results-Elevated weighted average PP during the first 60 hours was associated with poor outcome by mortality, Barthel index, National Institutes of Health Stroke Score (NIHSS) and Rankin scores. Elevated baseline PP was associated with Barthel index and Rankin score.Conclusion-Elevated PP is associated with poor stroke outcome at 3 months.

AB - Background-It is controversial which component of blood pressure (BP) during acute period of stroke best predicts outcome. We hypothesized that elevated pulse pressure (PP), the difference between systolic BP (SBP) and diastolic BP (DBP), is independently associated with poor stroke outcome at 3 months.Methods-We analyzed both treatment groups from the Glycine Antagonist (Gavestinel) in Neuroprotection (GAIN) International trial (1455 ischemic stroke cases of mostly moderate severity). Cox proportional hazards and logistic regression modeling corrected for demography, medical history, heart rate, stroke severity, and clinical subtype.Results-Elevated weighted average PP during the first 60 hours was associated with poor outcome by mortality, Barthel index, National Institutes of Health Stroke Score (NIHSS) and Rankin scores. Elevated baseline PP was associated with Barthel index and Rankin score.Conclusion-Elevated PP is associated with poor stroke outcome at 3 months.

KW - ischemia

KW - stroke

KW - outcome

KW - BLOOD-PRESSURE

KW - TRIAL

U2 - 10.1161/01.STR.0000126598.88662.16

DO - 10.1161/01.STR.0000126598.88662.16

M3 - Article

SN - 0039-2499

VL - 35

SP - E153-E155

JO - Stroke

JF - Stroke

IS - 6

ER -

Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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