@article{e525112ab9344d74ab3bcb3d559c0ca6,
title = "Elimination of human rabies in Goa, India through an integrated One Health approach",
abstract = "Dog-mediated rabies kills tens of thousands of people each year in India, representing one third of the estimated global rabies burden. Whilst the World Health Organization (WHO), World Organization for Animal Health (OIE) and the Food and Agriculture Organization of the United Nations (FAO) have set a target for global dog-mediated human rabies elimination by 2030, examples of large-scale dog vaccination programs demonstrating elimination remain limited in Africa and Asia. We describe the development of a data-driven rabies elimination program from 2013 to 2019 in Goa State, India, culminating in human rabies elimination and a 92% reduction in monthly canine rabies cases. Smartphone technology enabled systematic spatial direction of remote teams to vaccinate over 95,000 dogs at 70% vaccination coverage, and rabies education teams to reach 150,000 children annually. An estimated 2249 disability-adjusted life years (DALYs) were averted over the program period at 526 USD per DALY, making the intervention 'very cost-effective' by WHO definitions. This One Health program demonstrates that human rabies elimination is achievable at the state level in India.",
author = "Gibson, {A D} and G Yale and J Corfmat and M Appupillai and Gigante, {C M} and M Lopes and U Betodkar and Costa, {N C} and Fernandes, {K A} and P Mathapati and Suryawanshi, {P M} and N Otter and G Thomas and P Ohal and I Airikkala-Otter and F Lohr and Rupprecht, {C E} and A King and D Sutton and I Deuzeman and Y Li and Wallace, {R M} and Mani, {R S} and G Gongal and Handel, {I G} and M Bronsvoort and V Naik and S Desai and S Mazeri and L Gamble and Mellanby, {R J}",
note = "Funding Information: The Goa rabies control program was funded by the Government of Goa and Dogs Trust Worldwide. MSD Animal Health donated all Nobivac{\textregistered} Rabies vaccines used in the program. Rotary International (Rotary Clubs of Gainesville USA, Mapusa, Panjim, Riveira, Miramar, Panjim Midtown, Gainesville Sunrise, and Downtown Gainesville) donated vehicles used in dog vaccination and post-vaccination surveys. The World Health Organization contributed to Lateral Flow Assays (Bionote). B.M.d.B. was supported by Biotechnology and Biological Sciences Research Council through the Institute Strategic Program funding (BB/ J004235/1 and BB/P013740/1). Phylogenetic analysis was funded in part by the Office of Advanced Molecular Detection and Global Health Security (United States Centers for Disease Control and Prevention). C.M.G. was supported in part by an appointment to the Research Participation Program at CDC, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. We thank all the staff of Mission Rabies and Worldwide Veterinary Service, volunteers, local government veterinarians, and NGOs who have supported and contributed to the success of the campaign. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the United States government or the Centers for Disease Control and Prevention. Use of trade names, product names, or commercial sources is for identification only and does not imply endorsement by the United States government. Funding Information: The Goa rabies control program was funded by the Government of Goa and Dogs Trust Worldwide. MSD Animal Health donated all Nobivac{\textregistered} Rabies vaccines used in the program. Rotary International (Rotary Clubs of Gainesville USA, Mapusa, Panjim, Riveira, Miramar, Panjim Midtown, Gainesville Sunrise, and Downtown Gainesville) donated vehicles used in dog vaccination and post-vaccination surveys. The World Health Organization contributed to Lateral Flow Assays (Bionote). B.M.d.B. was supported by Biotechnology and Biological Sciences Research Council through the Institute Strategic Program funding (BB/ J004235/1 and BB/P013740/1). Phylogenetic analysis was funded in part by the Office of Advanced Molecular Detection and Global Health Security (United States Centers for Disease Control and Prevention). C.M.G. was supported in part by an appointment to the Research Participation Program at CDC, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. We thank all the staff of Mission Rabies and Worldwide Veterinary Service, volunteers, local government veterinarians, and NGOs who have supported and contributed to the success of the campaign. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the United States government or the Centers for Disease Control and Prevention. Use of trade names, product names, or commercial sources is for identification only and does not imply endorsement by the United States government. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = may,
day = "19",
doi = "10.1038/s41467-022-30371-y",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}