Embryonic origin of the adult hematopoietic system: Advances and questions

Alexander Medvinsky, Stanislav Rybtsov, Samir Taoudi

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.

Original languageEnglish
Pages (from-to)1017-1031
Number of pages15
JournalDevelopment
Volume138
Issue number6
DOIs
Publication statusPublished - 15 Mar 2011

Keywords

  • AGM regions
  • yolk sac
  • placenta
  • dHSC
  • Pre-dHSC

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