Embryonic origin of the adult hematopoietic system: Advances and questions

Alexander Medvinsky; Stanislav Rybtsov; Samir Taoudi

doi:10.1242/dev.040998

Embryonic origin of the adult hematopoietic system: Advances and questions

Alexander Medvinsky, Stanislav Rybtsov, Samir Taoudi

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.

Original language	English
Pages (from-to)	1017-1031
Number of pages	15
Journal	Development
Volume	138
Issue number	6
DOIs	https://doi.org/10.1242/dev.040998
Publication status	Published - 15 Mar 2011

Keywords / Materials (for Non-textual outputs)

AGM regions
yolk sac
placenta
dHSC
Pre-dHSC

Access to Document

10.1242/dev.040998

TaoudiEtalDB2011EmbryonicOriginOfTheAdultHematopoieticFinal published version, 11.9 MB

Identification of functional domains in the AGM region linked to the hierarchical organisation of the developing haematopoietic stem cell lineage
Medvinsky, A.
BBSRC
1/01/10 → 31/12/13
Project: Research
Analysis of cellular mechanisms underlying haematopoietic stem cell (HSC) development using a novel in vitro system
Medvinsky, A.
BBSRC
1/07/06 → 30/06/09
Project: Research

Cite this

@article{2907e0d312344ff893de4f17724cadad,

title = "Embryonic origin of the adult hematopoietic system: Advances and questions",

abstract = "Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.",

keywords = "AGM regions, yolk sac, placenta, dHSC, Pre-dHSC",

author = "Alexander Medvinsky and Stanislav Rybtsov and Samir Taoudi",

year = "2011",

month = mar,

day = "15",

doi = "10.1242/dev.040998",

language = "English",

volume = "138",

pages = "1017--1031",

journal = "Development",

issn = "0950-1991",

publisher = "Company of Biologists Ltd",

number = "6",

}

TY - JOUR

T1 - Embryonic origin of the adult hematopoietic system

T2 - Advances and questions

AU - Medvinsky, Alexander

AU - Rybtsov, Stanislav

AU - Taoudi, Samir

PY - 2011/3/15

Y1 - 2011/3/15

N2 - Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.

AB - Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.

KW - AGM regions

KW - yolk sac

KW - placenta

KW - dHSC

KW - Pre-dHSC

U2 - 10.1242/dev.040998

DO - 10.1242/dev.040998

M3 - Literature review

SN - 0950-1991

VL - 138

SP - 1017

EP - 1031

JO - Development

JF - Development

IS - 6

ER -

Embryonic origin of the adult hematopoietic system: Advances and questions

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

Identification of functional domains in the AGM region linked to the hierarchical organisation of the developing haematopoietic stem cell lineage

Analysis of cellular mechanisms underlying haematopoietic stem cell (HSC) development using a novel in vitro system

Cite this