Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair

Dietmar Zaiss*, William C. Gause, Lisa C Osborne, David Artis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Type 2 inflammatory responses can be elicited by diverse stimuli, including toxins, venoms, allergens, and infectious agents, and play critical roles in resistance and tolerance associated with infection, wound healing, tissue repair, and tumor development. Emerging data suggest that in addition to characteristic type 2-associated cytokines, the epidermal growth factor (EGF)-like molecule Amphiregulin (AREG) might be a critical component of type 2-mediated resistance and tolerance. Notably, numerous studies demonstrate that in addition to the established role of epithelial- and mesenchymal-derived AREG, multiple leukocyte populations including mast cells, basophils, group 2 innate lymphoid cells (ILC2s), and a subset of tissue-resident regulatory CD4+ T cells can express AREG. In this review, we discuss recent advances in our understanding of the AREG-EGF receptor pathway and its involvement in infection and inflammation and propose a model for the function of this pathway in the context of resistance and tissue tolerance.
Original languageEnglish
Pages (from-to)216–226
Number of pages11
JournalImmunity
Volume42
Issue number2
DOIs
Publication statusPublished - 1 Jan 2015

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