Emerging Links between Lipid Droplets and Motor Neuron Diseases

Giuseppa Pennetta; Michael A Welte

doi:10.1016/j.devcel.2018.05.002

Emerging Links between Lipid Droplets and Motor Neuron Diseases

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Lipid droplets (LDs) are ubiquitous fat storage organelles and play key roles in lipid metabolism and energy homeostasis; in addition, they contribute to protein storage, folding, and degradation. However, a role for LDs in the nervous system remains largely unexplored. We discuss evidence supporting an intimate functional connection between LDs and motor neuron disease (MND) pathophysiology, examining how LD functions in systemic energy homeostasis, in neuron-glia metabolic coupling, and in protein folding and clearance may affect or contribute to disease pathology. An integrated understanding of LD biology and neurodegeneration may open the way for new therapeutic interventions.

Original language	English
Pages (from-to)	427-432
Number of pages	6
Journal	Developmental Cell
Volume	45
Issue number	4
Early online date	21 May 2018
DOIs	https://doi.org/10.1016/j.devcel.2018.05.002
Publication status	Published - 21 May 2018

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Journal Article

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10.1016/j.devcel.2018.05.002

DEVCEL_4207Accepted author manuscript, 585 KBLicence: CC BY-NC-ND

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title = "Emerging Links between Lipid Droplets and Motor Neuron Diseases",

abstract = "Lipid droplets (LDs) are ubiquitous fat storage organelles and play key roles in lipid metabolism and energy homeostasis; in addition, they contribute to protein storage, folding, and degradation. However, a role for LDs in the nervous system remains largely unexplored. We discuss evidence supporting an intimate functional connection between LDs and motor neuron disease (MND) pathophysiology, examining how LD functions in systemic energy homeostasis, in neuron-glia metabolic coupling, and in protein folding and clearance may affect or contribute to disease pathology. An integrated understanding of LD biology and neurodegeneration may open the way for new therapeutic interventions.",

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AU - Welte, Michael A

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AB - Lipid droplets (LDs) are ubiquitous fat storage organelles and play key roles in lipid metabolism and energy homeostasis; in addition, they contribute to protein storage, folding, and degradation. However, a role for LDs in the nervous system remains largely unexplored. We discuss evidence supporting an intimate functional connection between LDs and motor neuron disease (MND) pathophysiology, examining how LD functions in systemic energy homeostasis, in neuron-glia metabolic coupling, and in protein folding and clearance may affect or contribute to disease pathology. An integrated understanding of LD biology and neurodegeneration may open the way for new therapeutic interventions.

KW - Journal Article

U2 - 10.1016/j.devcel.2018.05.002

DO - 10.1016/j.devcel.2018.05.002

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JO - Developmental Cell

JF - Developmental Cell

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Emerging Links between Lipid Droplets and Motor Neuron Diseases

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