Emerging Molecular Imaging Targets and Tools for Myocardial Fibrosis Detection

Anna Barton, Evangelos Tzolos, Rong Bing, Trisha Singh, Wolfgang Weber, Markus Schwaiger, Zohreh Varasteh , Riemer H J A Slart, David E Newby, Marc R Dweck

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Myocardial fibrosis is the heart’s common healing response to injury. Whilst initially seeking to optimise the strength of diseased tissue, fibrosis can become maladaptive, producing stiff poorly functioning and pro-arrhythmic myocardium. Different patterns of fibrosis are associated with different myocardial disease states, but the presence and quantity of fibrosis largely confers adverse prognosis. Current imaging techniques can assess the extent and pattern of myocardial scarring, but lack specificity and detect the presence of established fibrosis when the window to modify this process may have ended. For the first time, novel molecular imaging methods, including 68Ga-fibroblast activation protein inhibitor positron emission tomography (68Ga-FAPI PET), may permit highly specific imaging of fibrosis activity. These approaches may facilitate earlier fibrosis detection, differentiation of active versus end-stage disease, and assessment of both disease progression and treatment-response thereby improving patient care and clinical outcomes.
Original languageEnglish
JournalEuropean Heart Journal - Cardiovascular Imaging
Publication statusPublished - 28 Dec 2022

Keywords / Materials (for Non-textual outputs)

  • Myocardial fibrosis
  • Fibrosis imaging
  • Molecular fibrosis imaging
  • Positron emission tomography and cardiovascular magnetic resonance
  • Fibroblast activation protein inhibitor


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