Emerging properties and functional consequences of noncoding transcription

Ryan Ard, Robin C. Allshire, Sebastian Marquardt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Eukaryotic genomes are rich in transcription units encoding “long noncoding RNAs” (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, support grows for the notion that the act of transcription rather than the RNA product itself is functionally important in many cases. Indeed, this alternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA function in organisms. Here, we highlight some of the recently emerging features that distinguish coding from noncoding transcription and discuss how these differences might have important implications for the functional consequences of noncoding transcription.

Original languageEnglish
Pages (from-to)357-367
Number of pages11
Issue number2
Publication statusPublished - 4 Oct 2017

Keywords / Materials (for Non-textual outputs)

  • Chromatin
  • Gene regulation
  • Long noncoding RNA (lncRNA)
  • Nascent transcription
  • Noncoding transcription
  • RNA Polymerase II transcription
  • Transcription cycle
  • Transcriptional interference


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