Emerging roles of non-coding RNAs in endothelial cell function

Tijana Mitić; Andrea Caporali

doi:10.1016/j.cophys.2023.100672

Emerging roles of non-coding RNAs in endothelial cell function

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Nearly 98% of the human genome is transcriptionally active but does not encode proteins, reflecting a wide range of non-coding genome with essential regulatory and structural roles. Understanding the endothelial cell function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. However, only a tiny portion of the human genome's non-coding region has been studied to understand their role in new mechanisms in endothelial cell biology. Herein, we provide an overview of the non-coding RNAs in endothelium. We also discuss the latest research focusing on canonical and non-canonical aspects in non-coding RNA biology, non-coding RNA, cell-to-cell communication, and transcriptional and epigenetic regulation by non-coding RNA in the endothelium.

Original language	English
Pages (from-to)	100672
Journal	Current opinion in physiology
Early online date	10 Apr 2023
DOIs	https://doi.org/10.1016/j.cophys.2023.100672
Publication status	E-pub ahead of print - 10 Apr 2023

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10.1016/j.cophys.2023.100672Licence: CC BY

Mitic&Caporali R2 finalAccepted author manuscript, 68.2 KBLicence: Creative Commons: Attribution (CC-BY)

https://linkinghub.elsevier.com/retrieve/pii/S2468867323000421

Research Excellence Award Number 3
Newby, D., Bailey, M., Baker, A., Dweck, M., Mills, N., Morton, N., Pearson, E., Reynolds, R., Semple, R. & Webster, S.
UK-based charities
1/04/19 → 31/03/24
Project: Research
Role of microRNA-26b in post-ischaemic angiogenesis
Caporali, A. & Baker, A.
UK-based charities
1/01/17 → 31/12/19
Project: Research

Cite this

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title = "Emerging roles of non-coding RNAs in endothelial cell function",

abstract = "Nearly 98% of the human genome is transcriptionally active but does not encode proteins, reflecting a wide range of non-coding genome with essential regulatory and structural roles. Understanding the endothelial cell function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. However, only a tiny portion of the human genome's non-coding region has been studied to understand their role in new mechanisms in endothelial cell biology. Herein, we provide an overview of the non-coding RNAs in endothelium. We also discuss the latest research focusing on canonical and non-canonical aspects in non-coding RNA biology, non-coding RNA, cell-to-cell communication, and transcriptional and epigenetic regulation by non-coding RNA in the endothelium. ",

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AU - Caporali, Andrea

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AB - Nearly 98% of the human genome is transcriptionally active but does not encode proteins, reflecting a wide range of non-coding genome with essential regulatory and structural roles. Understanding the endothelial cell function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. However, only a tiny portion of the human genome's non-coding region has been studied to understand their role in new mechanisms in endothelial cell biology. Herein, we provide an overview of the non-coding RNAs in endothelium. We also discuss the latest research focusing on canonical and non-canonical aspects in non-coding RNA biology, non-coding RNA, cell-to-cell communication, and transcriptional and epigenetic regulation by non-coding RNA in the endothelium.

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M3 - Article

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JO - Current opinion in physiology

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ER -

Emerging roles of non-coding RNAs in endothelial cell function

Abstract / Description of output

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Projects

Research Excellence Award Number 3

Role of microRNA-26b in post-ischaemic angiogenesis

Cite this