Projects per year
Abstract / Description of output
Nearly 98% of the human genome is transcriptionally active but does not encode proteins, reflecting a wide range of non-coding genome with essential regulatory and structural roles. Understanding the endothelial cell function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. However, only a tiny portion of the human genome's non-coding region has been studied to understand their role in new mechanisms in endothelial cell biology. Herein, we provide an overview of the non-coding RNAs in endothelium. We also discuss the latest research focusing on canonical and non-canonical aspects in non-coding RNA biology, non-coding RNA, cell-to-cell communication, and transcriptional and epigenetic regulation by non-coding RNA in the endothelium.
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1/01/17 → 31/12/19