Emphysema the challenge of the remodelled lung: the challenge of the remodelled lung

R Blundell, D J Harrison, William Wallace

Research output: Contribution to journalArticlepeer-review

Abstract

Emphysema is recognized as the component of chronic obstructive airways disease that is responsible for airways obstruction. Different patterns of emphysema are, however, recognized, suggesting possible different pathogenetic processes within the lung. This, coupled with the associated idea of susceptibility factors to the development of emphysema, has led to studies of genes that may be involved in the defence of the lung from proteolytic and oxidative damage. These studies have been driven by the goal of finding a treatment for emphysema, but appear to have lost sight of the fundamental remodelling of the lung that has occurred in patients with emphysema and the fact that it is not a single morphological entity.
Original languageEnglish
Pages (from-to)141-4
Number of pages4
JournalThe Journal of Pathology
Volume202
Issue number2
DOIs
Publication statusPublished - 2004

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