Tungsten catalysts with chiral phosphinooxazoline ligands react with 3-aryl-2-propenyl diethyl phosphates and the sodium salt of dimethyl malonate to give the corresponding chiral substitution products with regioselectivities of 3-24:1 and 88-96% ee. A new class of chiral P,N-ligands has been developed which allow efficient regio- and enantiocontrol in analogous Pd-catalyzed allylic substitutions of 1- and 3-aryl-2-propenyl acetates with dimethyl malonate.
|Number of pages||6|
|Journal||Pure and applied chemistry|
|Publication status||Published - May 1998|
|Event||9th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS-9) - GOTTINGEN, Germany|
Duration: 20 Jul 1997 → 25 Jul 1997
- ASYMMETRIC CATALYSIS
- CHIRAL LIGANDS