Enantioselective Nickel-Catalyzed Michael Additions of Azaarylacetates and Acetamides to Nitroalkenes

Charlene Fallan; Hon Lam

doi:10.1002/chem.201202093

Enantioselective Nickel-Catalyzed Michael Additions of Azaarylacetates and Acetamides to Nitroalkenes

Charlene Fallan, Hon Lam

Research output: Contribution to journal › Article › peer-review

Abstract

Put a nickel in it: Azaarylacetates and acetamides, which have been neglected as substrates in catalytic asymmetric synthesis, undergo highly enantioselective Michael additions to nitroalkenes in the presence of a chiral nickel(II)-bis(diamine) complex (see scheme; Bn=benzyl, MS=molecular sieves). This process is tolerant of a wide variety of azaarenes in the pronucleophile.

Original language	English
Pages (from-to)	11214-11218
Number of pages	5
Journal	Chemistry - A European Journal
Volume	18
Issue number	36
DOIs	https://doi.org/10.1002/chem.201202093
Publication status	Published - 3 Sept 2012

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title = "Enantioselective Nickel-Catalyzed Michael Additions of Azaarylacetates and Acetamides to Nitroalkenes",

abstract = "Put a nickel in it: Azaarylacetates and acetamides, which have been neglected as substrates in catalytic asymmetric synthesis, undergo highly enantioselective Michael additions to nitroalkenes in the presence of a chiral nickel(II)-bis(diamine) complex (see scheme; Bn=benzyl, MS=molecular sieves). This process is tolerant of a wide variety of azaarenes in the pronucleophile.",

author = "Charlene Fallan and Hon Lam",

year = "2012",

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AU - Lam, Hon

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N2 - Put a nickel in it: Azaarylacetates and acetamides, which have been neglected as substrates in catalytic asymmetric synthesis, undergo highly enantioselective Michael additions to nitroalkenes in the presence of a chiral nickel(II)-bis(diamine) complex (see scheme; Bn=benzyl, MS=molecular sieves). This process is tolerant of a wide variety of azaarenes in the pronucleophile.

AB - Put a nickel in it: Azaarylacetates and acetamides, which have been neglected as substrates in catalytic asymmetric synthesis, undergo highly enantioselective Michael additions to nitroalkenes in the presence of a chiral nickel(II)-bis(diamine) complex (see scheme; Bn=benzyl, MS=molecular sieves). This process is tolerant of a wide variety of azaarenes in the pronucleophile.

U2 - 10.1002/chem.201202093

DO - 10.1002/chem.201202093

M3 - Article

SN - 0947-6539

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 36

ER -

Enantioselective Nickel-Catalyzed Michael Additions of Azaarylacetates and Acetamides to Nitroalkenes

Abstract

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