Abstract
Put a nickel in it: Azaarylacetates and acetamides, which have been neglected as substrates in catalytic asymmetric synthesis, undergo highly enantioselective Michael additions to nitroalkenes in the presence of a chiral nickel(II)-bis(diamine) complex (see scheme; Bn=benzyl, MS=molecular sieves). This process is tolerant of a wide variety of azaarenes in the pronucleophile.
Original language | English |
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Pages (from-to) | 11214-11218 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 18 |
Issue number | 36 |
DOIs | |
Publication status | Published - 3 Sept 2012 |