Enantioselective Nickel-Catalyzed Michael Additions of Azaarylacetates and Acetamides to Nitroalkenes

Charlene Fallan, [No Value] Hon Wai Lam, Hon Lam

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Put a nickel in it: Azaarylacetates and acetamides, which have been neglected as substrates in catalytic asymmetric synthesis, undergo highly enantioselective Michael additions to nitroalkenes in the presence of a chiral nickel(II)-bis(diamine) complex (see scheme; Bn=benzyl, MS=molecular sieves). This process is tolerant of a wide variety of azaarenes in the pronucleophile.
Original languageEnglish
Pages (from-to)11214-11218
Number of pages5
JournalChemistry - A European Journal
Issue number36
Publication statusPublished - 3 Sep 2012

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