Enantioselective rhodium-catalyzed arylation of electron-deficient alkenylarenes

Aakarsh Saxena, Hon Wai Lam

Research output: Contribution to journalArticlepeer-review

Abstract

beta-Substituted alkenyl-para-nitroarenes, an unexplored substrate class for catalytic asymmetric addition reactions, undergo highly enantioselective rhodium-catalyzed arylations with arylboronic acids in the presence of a dibenzylamide-containing chiral diene ligand. One example of the asymmetric arylation of an alkenyl-p-cyano-m-(trifluoromethyl)benzene is also presented.

Original languageEnglish
Pages (from-to)2326-2331
Number of pages6
JournalChemical Science
Volume2
Issue number12
DOIs
Publication statusPublished - 2011

Keywords

  • ASYMMETRIC CONJUGATE ADDITION
  • CHIRAL DIENE LIGANDS
  • POTASSIUM TERT-BUTOXIDE
  • ARYLBORONIC ACIDS
  • ORGANOBORONIC ACIDS
  • GRIGNARD-REAGENTS
  • ALPHA,BETA-UNSATURATED ESTERS
  • CINNAMYL DERIVATIVES
  • ALKENYLBORONIC ACIDS
  • COUPLING REACTIONS

Fingerprint

Dive into the research topics of 'Enantioselective rhodium-catalyzed arylation of electron-deficient alkenylarenes'. Together they form a unique fingerprint.

Cite this