Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude

J Kenneth Baillie, Matthew G D Bates, A A Roger Thompson, W Stephen Waring, Roland W Partridge, Martin F Schnopp, Alistair Simpson, Fiona Gulliver-Sloan, Simon R J Maxwell, David J Webb

Research output: Contribution to journalArticlepeer-review

Abstract

Both tissue hypoxia in vitro, and whole-body hypoxia in vivo, have been found to promote the release of reactive oxygen species (ROS) that are potentially damaging to the cardiovascular system. Antioxidant systems protect against oxidative damage by ROS and may exhibit some degree of responsiveness to oxidative stimuli. Production of urate, a potent soluble antioxidant, is increased in hypoxic conditions. We aimed to determine whether urate is an important antioxidant defense in healthy subjects exposed to hypoxia.
Original languageEnglish
Pages (from-to)1473-8
Number of pages6
JournalChest
Volume131
Issue number5
DOIs
Publication statusPublished - 2007

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