Endometriosis: cannabidiol therapy for symptom relief

Research output: Contribution to journalReview articlepeer-review

Abstract

Endometriosis is a common, chronic, incurable, condition the hallmark of which is the
presence of lesions (tissue resembling endometrium) in sites outside the womb.
Symptoms include chronic debilitating pain and fatigue: current therapeutic options are
limited. Recent advances in our understanding of the mechanisms that contribute to
development of lesions and pain experience in endometriosis as well as surveys of
patients have increased interest in testing recently approved formulations containing
cannabidiol (CBD) in this patient group. In this review we summarise data from patient
samples and animals models focused on the pathophysiology of endometriosis
including pathways where CBD has activity. We consider, the available formulations of
CBD-containing products, their pharmacokinetics, and their use in ongoing clinical
trials in endometriosis and other pain conditions.
Original languageEnglish
Pages (from-to)1150-1161
JournalTrends in Pharmacological Sciences
Volume45
Issue number12
Early online date14 Nov 2024
DOIs
Publication statusPublished - 5 Dec 2024

Keywords / Materials (for Non-textual outputs)

  • cannabidiol
  • endometriosis
  • endocannabinoids
  • pain
  • inflammation

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