Abstract
Endometriosis is a common, chronic, incurable, condition the hallmark of which is the
presence of lesions (tissue resembling endometrium) in sites outside the womb.
Symptoms include chronic debilitating pain and fatigue: current therapeutic options are
limited. Recent advances in our understanding of the mechanisms that contribute to
development of lesions and pain experience in endometriosis as well as surveys of
patients have increased interest in testing recently approved formulations containing
cannabidiol (CBD) in this patient group. In this review we summarise data from patient
samples and animals models focused on the pathophysiology of endometriosis
including pathways where CBD has activity. We consider, the available formulations of
CBD-containing products, their pharmacokinetics, and their use in ongoing clinical
trials in endometriosis and other pain conditions.
presence of lesions (tissue resembling endometrium) in sites outside the womb.
Symptoms include chronic debilitating pain and fatigue: current therapeutic options are
limited. Recent advances in our understanding of the mechanisms that contribute to
development of lesions and pain experience in endometriosis as well as surveys of
patients have increased interest in testing recently approved formulations containing
cannabidiol (CBD) in this patient group. In this review we summarise data from patient
samples and animals models focused on the pathophysiology of endometriosis
including pathways where CBD has activity. We consider, the available formulations of
CBD-containing products, their pharmacokinetics, and their use in ongoing clinical
trials in endometriosis and other pain conditions.
Original language | English |
---|---|
Pages (from-to) | 1150-1161 |
Journal | Trends in Pharmacological Sciences |
Volume | 45 |
Issue number | 12 |
Early online date | 14 Nov 2024 |
DOIs | |
Publication status | Published - 5 Dec 2024 |
Keywords / Materials (for Non-textual outputs)
- cannabidiol
- endometriosis
- endocannabinoids
- pain
- inflammation