Endoscopic sensing of alveolar pH

D. Choudhury, M. G. Tanner, S. Mcaughtrie, F. Yu, B. Mills, T. R. Choudhary, S. Seth, Tom Craven, J. M. Stone, I. K. Mati, C. J. Campbell, M. Bradley, C. K. I. Williams, K. Dhaliwal, T. A. Birks, R. R. Thomson

Research output: Contribution to journalArticlepeer-review

Abstract

Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multip le site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.
Original languageEnglish
Pages (from-to)243
JournalBiomedical Optics Express
Volume8
Issue number1
DOIs
Publication statusPublished - 13 Dec 2016

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