Endoscopic sensing of alveolar pH

D. Choudhury; M. G. Tanner; S. Mcaughtrie; F. Yu; B. Mills; T. R. Choudhary; S. Seth; Tom Craven; J. M. Stone; I. K. Mati; C. J. Campbell; M. Bradley; C. K. I. Williams; K. Dhaliwal; T. A. Birks; R. R. Thomson

doi:10.1364/BOE.8.000243

Endoscopic sensing of alveolar pH

D. Choudhury, M. G. Tanner, S. Mcaughtrie, F. Yu, B. Mills, T. R. Choudhary, S. Seth, Tom Craven, J. M. Stone, I. K. Mati, C. J. Campbell, M. Bradley, C. K. I. Williams, K. Dhaliwal, T. A. Birks, R. R. Thomson

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multip le site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

Original language	English
Pages (from-to)	243
Journal	Biomedical Optics Express
Volume	8
Issue number	1
DOIs	https://doi.org/10.1364/BOE.8.000243
Publication status	Published - 13 Dec 2016

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10.1364/BOE.8.000243

boe-8-1-243
© 2016 Optical Society of America
Final published version, 5.23 MBLicence: Creative Commons: Attribution (CC-BY)

https://www.osapublishing.org/abstract.cfm?URI=boe-8-1-243

Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging
Haslett, C.
EPSRC
1/10/13 → 31/03/19
Project: Research
Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging
Henderson, R.
EPSRC
1/10/13 → 31/03/19
Project: Research

Cite this

@article{f53e320e959d4253a9e5260a54ec6e45,

title = "Endoscopic sensing of alveolar pH",

abstract = "Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multip le site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation. ",

author = "D. Choudhury and Tanner, {M. G.} and S. Mcaughtrie and F. Yu and B. Mills and Choudhary, {T. R.} and S. Seth and Tom Craven and Stone, {J. M.} and Mati, {I. K.} and Campbell, {C. J.} and M. Bradley and Williams, {C. K. I.} and K. Dhaliwal and Birks, {T. A.} and Thomson, {R. R.}",

year = "2016",

month = dec,

day = "13",

doi = "10.1364/BOE.8.000243",

language = "English",

volume = "8",

pages = "243",

journal = "Biomedical Optics Express",

issn = "2156-7085",

publisher = "The Optical Society",

number = "1",

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TY - JOUR

T1 - Endoscopic sensing of alveolar pH

AU - Choudhury, D.

AU - Tanner, M. G.

AU - Mcaughtrie, S.

AU - Yu, F.

AU - Mills, B.

AU - Choudhary, T. R.

AU - Seth, S.

AU - Craven, Tom

AU - Stone, J. M.

AU - Mati, I. K.

AU - Campbell, C. J.

AU - Bradley, M.

AU - Williams, C. K. I.

AU - Dhaliwal, K.

AU - Birks, T. A.

AU - Thomson, R. R.

PY - 2016/12/13

Y1 - 2016/12/13

N2 - Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multip le site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

AB - Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multip le site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

U2 - 10.1364/BOE.8.000243

DO - 10.1364/BOE.8.000243

M3 - Article

SN - 2156-7085

VL - 8

SP - 243

JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 1

ER -

Endoscopic sensing of alveolar pH

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Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging

Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging

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