Endosomal trafficking of Src tyrosine kinase

Emma Sandilands, Margaret C Frame

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Endosomal trafficking is an essential cellular process involved in the transport of proteins such as integrins, hormone receptors, growth factor receptors, receptor tyrosine kinases, and lipids (e.g. sphingomyelin). Regulation of this process is highly complex and involves Arf GAPs, SNAREs, Rab proteins, Rho GTPases and the actin cytoskeleton. In this article, we focus on the intracellular targeting of the Src family of non-receptor tyrosine kinases (nRTKs), and the role of endosomes in the delivery of nRTKs to the plasma membrane. Furthermore, we discuss the role of the actin cytoskeleton in this process and consider how endosome-regulated intracellular trafficking affects cell signalling.
Original languageEnglish
Pages (from-to)322-9
Number of pages8
JournalTrends In Cell Biology
Volume18
Issue number7
DOIs
Publication statusPublished - 2008

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