Endothelia-1([1-31]) is not elevated in men with chronic heart failure

SJ Leslie*, N Johnston, FE Strachan, A Bagnall, GA Gray, DE Newby, MA Denvir, DJ Webb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Endothelin-1([1-31]) is a recently discovered member of the endothelin family with vasoactive properties in several animal models and in man in vivo. It is generated from big endothelin-1 by human mast cell chymase and may be a novel intermediary peptide in the production of endothelia-1([1-21]). Given that both big endothelia-1([1-38]) and chymase activity are increased in chronic heart failure, the aim of this study was to determine whether plasma endothelia-1([1-31]) concentrations are elevated in patients with chronic heart failure. Plasma endothelin-1[1-31] concentrations were measured by enzyme-linked immunosorbent assay in nine patients with chronic heart failure, and nine age- and sex-matched control subjects. Consistent with previous studies, plasma concentrations of big endothelia-1([1-38]) were elevated in patients compared with controls (17.1 +/- 4.4 pg/mL vs 8.9 +/- 3.4 pg/mL, P = 0.002), although there were no differences in plasma endothelia-1([1-21]) (3.3 +/- 0.4 pg/mL vs 3.4 +/- 0.7 pg/mL, P= 0.7) or endothelia-1([1-31]) (both 1.1 +/- 0.1 pg/mL, P = 0.2) concentrations. We have demonstrated that patients with chronic heart failure have normal plasma endothelia-1([1-31]) concentrations. This suggests that, in contrast to big endothelia-1([1-38]), plasma endothelia-1([1-31]) is unlikely to be a useful prognostic marker in patients with chronic heart failure.

Original languageEnglish
Pages (from-to)S96-S99
Number of pages4
JournalJournal of cardiovascular pharmacology
Volume44
Publication statusPublished - Nov 2004

Keywords / Materials (for Non-textual outputs)

  • endothelia-1([1-31]) (ET-1([1-31]))
  • chronic heart failure (CHF)
  • assay
  • neuroendocrine
  • ACTIVATED MAST-CELLS
  • SMOOTH-MUSCLE
  • ANGIOTENSIN-II
  • ENDOTHELINS
  • CHYMASE
  • PEPTIDE
  • RUPTURE
  • SITE

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