Endothelial cell-oligodendrocyte interactions in small vessel disease and aging

Rikesh M Rajani, Anna Williams

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly increases the risk of stroke and dementia. The main pathological changes are vascular, in the form of lipohyalinosis and arteriosclerosis, and in the white matter (WM), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved-the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM-interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes in SVD. As these interactions have been studied in more detail in other disease states and in development, we explore these systems and discuss the role these mechanisms may play in SVD.

Original languageEnglish
Pages (from-to)369-379
Number of pages11
JournalClinical science
Volume131
Issue number5
Early online date15 Feb 2017
DOIs
Publication statusPublished - Mar 2017

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