Endothelial-derived selectins in the development of organ dysfunction in acute pancreatitis

J J Powell; A K Siriwardena; K C Fearon; J A Ross

Endothelial-derived selectins in the development of organ dysfunction in acute pancreatitis

J J Powell, A K Siriwardena, K C Fearon, J A Ross

School of Regeneration and Repair

Research output: Contribution to journal › Article › peer-review

Abstract

The development of organ dysfunction is the principal determinant of outcome in acute pancreatitis and is mediated through a systemic inflammatory response characterized by leukocyte and endothelial cell activation. Up-regulation of the endothelial cell adhesion molecules, E-selectin and P-selectin, is important for endothelial/leukocyte interactions. Levels of serum-soluble E-selectin and P-selectin have been suggested as markers of endothelial activation. This study examines the kinetics of serum-soluble selectins in patients with acute pancreatitis complicated by organ dysfunction.

Original language	English
Pages (from-to)	567-72
Number of pages	6
Journal	Critical Care Medicine
Volume	29
Issue number	3
Publication status	Published - 2001

Cite this

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title = "Endothelial-derived selectins in the development of organ dysfunction in acute pancreatitis",

abstract = "The development of organ dysfunction is the principal determinant of outcome in acute pancreatitis and is mediated through a systemic inflammatory response characterized by leukocyte and endothelial cell activation. Up-regulation of the endothelial cell adhesion molecules, E-selectin and P-selectin, is important for endothelial/leukocyte interactions. Levels of serum-soluble E-selectin and P-selectin have been suggested as markers of endothelial activation. This study examines the kinetics of serum-soluble selectins in patients with acute pancreatitis complicated by organ dysfunction.",

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N2 - The development of organ dysfunction is the principal determinant of outcome in acute pancreatitis and is mediated through a systemic inflammatory response characterized by leukocyte and endothelial cell activation. Up-regulation of the endothelial cell adhesion molecules, E-selectin and P-selectin, is important for endothelial/leukocyte interactions. Levels of serum-soluble E-selectin and P-selectin have been suggested as markers of endothelial activation. This study examines the kinetics of serum-soluble selectins in patients with acute pancreatitis complicated by organ dysfunction.

AB - The development of organ dysfunction is the principal determinant of outcome in acute pancreatitis and is mediated through a systemic inflammatory response characterized by leukocyte and endothelial cell activation. Up-regulation of the endothelial cell adhesion molecules, E-selectin and P-selectin, is important for endothelial/leukocyte interactions. Levels of serum-soluble E-selectin and P-selectin have been suggested as markers of endothelial activation. This study examines the kinetics of serum-soluble selectins in patients with acute pancreatitis complicated by organ dysfunction.

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C2 - 11373422

SN - 0090-3493

VL - 29

SP - 567

EP - 572

JO - Critical Care Medicine

JF - Critical Care Medicine

IS - 3

ER -

Endothelial-derived selectins in the development of organ dysfunction in acute pancreatitis

Abstract

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