Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade

Jane Goddard; Neil R Johnston; Malcolm F Hand; Allan D Cumming; Ton J Rabelink; Andrew J Rankin; David J Webb

doi:10.1161/01.CIR.0000118499.69469.51

Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade

Jane Goddard, Neil R Johnston, Malcolm F Hand, Allan D Cumming, Ton J Rabelink, Andrew J Rankin, David J Webb

Research output: Contribution to journal › Article › peer-review

Abstract

Endothelin (ET) is implicated in the pathophysiology of chronic renal failure (CRF). We therefore studied the systemic and renal hemodynamic effects of ET receptor antagonists in CRF and examined differences between selective ETA, selective ETB, and combined ETA/B receptor blockade.

Original language	English
Pages (from-to)	1186-93
Number of pages	8
Journal	Circulation
Volume	109
Issue number	9
DOIs	https://doi.org/10.1161/01.CIR.0000118499.69469.51
Publication status	Published - 23 Feb 2004

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Goddard, J., Johnston, N. R., Hand, M. F., Cumming, A. D., Rabelink, T. J., Rankin, A. J., & Webb, D. J. (2004). Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade. Circulation, 109(9), 1186-93. https://doi.org/10.1161/01.CIR.0000118499.69469.51

Goddard, Jane ; Johnston, Neil R ; Hand, Malcolm F ; Cumming, Allan D ; Rabelink, Ton J ; Rankin, Andrew J ; Webb, David J. / Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure : a comparison of selective and combined endothelin receptor blockade. In: Circulation. 2004 ; Vol. 109, No. 9. pp. 1186-93.

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title = "Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade",

abstract = "Endothelin (ET) is implicated in the pathophysiology of chronic renal failure (CRF). We therefore studied the systemic and renal hemodynamic effects of ET receptor antagonists in CRF and examined differences between selective ETA, selective ETB, and combined ETA/B receptor blockade.",

author = "Jane Goddard and Johnston, {Neil R} and Hand, {Malcolm F} and Cumming, {Allan D} and Rabelink, {Ton J} and Rankin, {Andrew J} and Webb, {David J}",

year = "2004",

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doi = "10.1161/01.CIR.0000118499.69469.51",

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Goddard, J, Johnston, NR, Hand, MF, Cumming, AD, Rabelink, TJ, Rankin, AJ & Webb, DJ 2004, 'Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade', Circulation, vol. 109, no. 9, pp. 1186-93. https://doi.org/10.1161/01.CIR.0000118499.69469.51

Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure : a comparison of selective and combined endothelin receptor blockade. / Goddard, Jane; Johnston, Neil R; Hand, Malcolm F; Cumming, Allan D; Rabelink, Ton J; Rankin, Andrew J; Webb, David J.

In: Circulation, Vol. 109, No. 9, 23.02.2004, p. 1186-93.

Research output: Contribution to journal › Article › peer-review

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T1 - Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure

T2 - a comparison of selective and combined endothelin receptor blockade

AU - Goddard, Jane

AU - Johnston, Neil R

AU - Hand, Malcolm F

AU - Cumming, Allan D

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AU - Rankin, Andrew J

AU - Webb, David J

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AB - Endothelin (ET) is implicated in the pathophysiology of chronic renal failure (CRF). We therefore studied the systemic and renal hemodynamic effects of ET receptor antagonists in CRF and examined differences between selective ETA, selective ETB, and combined ETA/B receptor blockade.

U2 - 10.1161/01.CIR.0000118499.69469.51

DO - 10.1161/01.CIR.0000118499.69469.51

M3 - Article

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Goddard J, Johnston NR, Hand MF, Cumming AD, Rabelink TJ, Rankin AJ et al. Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade. Circulation. 2004 Feb 23;109(9):1186-93. https://doi.org/10.1161/01.CIR.0000118499.69469.51