Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade

Jane Goddard, Neil R Johnston, Malcolm F Hand, Allan D Cumming, Ton J Rabelink, Andrew J Rankin, David J Webb

Research output: Contribution to journalArticlepeer-review

Abstract

Endothelin (ET) is implicated in the pathophysiology of chronic renal failure (CRF). We therefore studied the systemic and renal hemodynamic effects of ET receptor antagonists in CRF and examined differences between selective ETA, selective ETB, and combined ETA/B receptor blockade.
Original languageEnglish
Pages (from-to)1186-93
Number of pages8
JournalCirculation
Volume109
Issue number9
DOIs
Publication statusPublished - 23 Feb 2004

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