Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide

Stephen J Leslie, Mamun Q Rahman, Martin A Denvir, David E Newby, David J Webb

Research output: Contribution to journalArticlepeer-review

Abstract

Endothelin-1 (ET-1([1-21])) is an extremely potent vasoconstrictor in the human skin microcirculation and is generated from larger precursor peptides. The aims of the present study were to assess the vasoactive effects of these precursors as well as endothelin blockade in the human skin microcirculation, in vivo.
Original languageEnglish
Pages (from-to)720-5
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Volume57
Issue number6
DOIs
Publication statusPublished - 2004

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