Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide

Stephen J Leslie; Mamun Q Rahman; Martin A Denvir; David E Newby; David J Webb

doi:10.1111/j.1365-2125.2004.02074.x

Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide

Stephen J Leslie, Mamun Q Rahman, Martin A Denvir, David E Newby, David J Webb

Research output: Contribution to journal › Article › peer-review

Abstract

Endothelin-1 (ET-1([1-21])) is an extremely potent vasoconstrictor in the human skin microcirculation and is generated from larger precursor peptides. The aims of the present study were to assess the vasoactive effects of these precursors as well as endothelin blockade in the human skin microcirculation, in vivo.

Original language	English
Pages (from-to)	720-5
Number of pages	6
Journal	British Journal of Clinical Pharmacology
Volume	57
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2125.2004.02074.x
Publication status	Published - 2004

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10.1111/j.1365-2125.2004.02074.x

Endothelins and their inhibition in the human skin microcirculation_ ET[1–31], a
Copyright © 2004 Blackwell Publishing Ltd. OnlineOpen article
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884515/

Cite this

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title = "Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide",

abstract = "Endothelin-1 (ET-1([1-21])) is an extremely potent vasoconstrictor in the human skin microcirculation and is generated from larger precursor peptides. The aims of the present study were to assess the vasoactive effects of these precursors as well as endothelin blockade in the human skin microcirculation, in vivo.",

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AU - Rahman, Mamun Q

AU - Denvir, Martin A

AU - Newby, David E

AU - Webb, David J

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AB - Endothelin-1 (ET-1([1-21])) is an extremely potent vasoconstrictor in the human skin microcirculation and is generated from larger precursor peptides. The aims of the present study were to assess the vasoactive effects of these precursors as well as endothelin blockade in the human skin microcirculation, in vivo.

U2 - 10.1111/j.1365-2125.2004.02074.x

DO - 10.1111/j.1365-2125.2004.02074.x

M3 - Article

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SP - 720

EP - 725

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

SN - 0306-5251

IS - 6

ER -

Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide

Abstract

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