Enfermedad antimembrana basal glomerular en un paciente transplantado renal con enfermedad de Alport

G Soler Pujol; R Iotti; M Dávalos Michel; A R Vilches; A Neil Turner

Enfermedad antimembrana basal glomerular en un paciente transplantado renal con enfermedad de Alport

Translated title of the contribution: Anti glomerular basement membrane disease in a renal transplant patient with Alport syndrome

G Soler Pujol, R Iotti, M Dávalos Michel, A R Vilches, A Neil Turner

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

We report a case of anti GBM disease that developed in the renal graft of a patient with Alport syndrome. After reaching abnormal values of creatinine, the patient presented with deteriorating renal function three months after a cadaver transplant and the biopsy showed crescent formation, and linear IF deposits. Circulating antibodies against alpha 5 chain of type IV collagen were found and plasmaphereses stabilized the condition for one year until a lung infection led to withdrawal of the immunosuppressive drugs and the patient returned to dialysis. We discuss the possible mechanisms underlying the specificity of the circulating antibodies in this case, which differs from the target characteristic of the idiopathic form of anti GBM disease, the alpha 3 (IV) chain.

Translated title of the contribution	Anti glomerular basement membrane disease in a renal transplant patient with Alport syndrome
Original language	Spanish
Pages (from-to)	466-8
Number of pages	3
Journal	Medicina Clínica
Volume	59
Issue number	5 Pt 1
Publication status	Published - 1999

Keywords / Materials (for Non-textual outputs)

Adult
Anti-Glomerular Basement Membrane Disease
Graft Rejection
Humans
Kidney Transplantation
Male
Nephritis, Hereditary
Plasmapheresis

Cite this

@article{ca4963b56e214b69a0a79c05bfa530bd,

title = "Enfermedad antimembrana basal glomerular en un paciente transplantado renal con enfermedad de Alport",

abstract = "We report a case of anti GBM disease that developed in the renal graft of a patient with Alport syndrome. After reaching abnormal values of creatinine, the patient presented with deteriorating renal function three months after a cadaver transplant and the biopsy showed crescent formation, and linear IF deposits. Circulating antibodies against alpha 5 chain of type IV collagen were found and plasmaphereses stabilized the condition for one year until a lung infection led to withdrawal of the immunosuppressive drugs and the patient returned to dialysis. We discuss the possible mechanisms underlying the specificity of the circulating antibodies in this case, which differs from the target characteristic of the idiopathic form of anti GBM disease, the alpha 3 (IV) chain.",

keywords = "Adult, Anti-Glomerular Basement Membrane Disease, Graft Rejection, Humans, Kidney Transplantation, Male, Nephritis, Hereditary, Plasmapheresis",

author = "{Soler Pujol}, G and R Iotti and {D{\'a}valos Michel}, M and Vilches, {A R} and Turner, {A Neil}",

year = "1999",

language = "Spanish",

volume = "59",

pages = "466--8",

journal = "Medicina Cl{\'i}nica",

issn = "0025-7680",

publisher = "Instituto de Investigaciones Medicas",

number = "5 Pt 1",

}

TY - JOUR

T1 - Enfermedad antimembrana basal glomerular en un paciente transplantado renal con enfermedad de Alport

AU - Soler Pujol, G

AU - Iotti, R

AU - Dávalos Michel, M

AU - Vilches, A R

AU - Turner, A Neil

PY - 1999

Y1 - 1999

N2 - We report a case of anti GBM disease that developed in the renal graft of a patient with Alport syndrome. After reaching abnormal values of creatinine, the patient presented with deteriorating renal function three months after a cadaver transplant and the biopsy showed crescent formation, and linear IF deposits. Circulating antibodies against alpha 5 chain of type IV collagen were found and plasmaphereses stabilized the condition for one year until a lung infection led to withdrawal of the immunosuppressive drugs and the patient returned to dialysis. We discuss the possible mechanisms underlying the specificity of the circulating antibodies in this case, which differs from the target characteristic of the idiopathic form of anti GBM disease, the alpha 3 (IV) chain.

AB - We report a case of anti GBM disease that developed in the renal graft of a patient with Alport syndrome. After reaching abnormal values of creatinine, the patient presented with deteriorating renal function three months after a cadaver transplant and the biopsy showed crescent formation, and linear IF deposits. Circulating antibodies against alpha 5 chain of type IV collagen were found and plasmaphereses stabilized the condition for one year until a lung infection led to withdrawal of the immunosuppressive drugs and the patient returned to dialysis. We discuss the possible mechanisms underlying the specificity of the circulating antibodies in this case, which differs from the target characteristic of the idiopathic form of anti GBM disease, the alpha 3 (IV) chain.

KW - Adult

KW - Anti-Glomerular Basement Membrane Disease

KW - Graft Rejection

KW - Humans

KW - Kidney Transplantation

KW - Male

KW - Nephritis, Hereditary

KW - Plasmapheresis

M3 - Article

C2 - 10684168

SN - 0025-7680

VL - 59

SP - 466

EP - 468

JO - Medicina Clínica

JF - Medicina Clínica

IS - 5 Pt 1

ER -

Enfermedad antimembrana basal glomerular en un paciente transplantado renal con enfermedad de Alport

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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