Engineered and designed peptide-based fibrous biomaterials

C E MacPhee, D N Woolfson, Cait MacPhee

Research output: Contribution to journalArticlepeer-review

Abstract

Our increasing understanding of peptide and protein folding and assembly raises new possibilities for engineering novel self-assembling supramolecular structures and bio-inspired materials. Here we focus on peptides designed de novo, and natural systems that have been engineered to form extended protein fibres. Potential applications of such assemblies include the preparation of functionalised biomaterials for the development of new diagnostic devices, scaffolds to recruit cells for cell/tissue engineering, and templates for the assembly of inorganic materials. (C) 2004 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalCurrent Opinion in Solid State and Materials Science
Volume8
Issue number2
DOIs
Publication statusPublished - Mar 2004

Keywords

  • alpha-helix
  • amyloid fibril
  • beta-sheet
  • coiled coil
  • fibre
  • nanotechnology
  • peptide
  • protein
  • protein design
  • AMYLOID FIBRIL FORMATION
  • SELF-COMPLEMENTARY OLIGOPEPTIDE
  • UNDERGO STRUCTURAL TRANSITION
  • DE-NOVO DESIGN
  • BETA-SHEET
  • COILED COILS
  • ALPHA-HELIX
  • STREPTOMYCES-COELICOLOR
  • HUNTINGTONS-DISEASE
  • PROTEIN-DESIGN

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