Engineered muscle: A tool for studying muscle physiology and function

Alastair Khodabukus; Jennifer Z. Paxton; Kenneth Donnelly; Keith Baar

Engineered muscle: A tool for studying muscle physiology and function

Alastair Khodabukus, Jennifer Z. Paxton, Kenneth Donnelly, Keith Baar^*

^*Corresponding author for this work

Deanery of Biomedical Sciences

Research output: Contribution to journal › Literature review › peer-review

Abstract

Recent advances in skeletal muscle tissue engineering have resulted in an in vitro tissue model that can be used for studying the effects of genetic alterations, pharmacological interventions, and exercise on muscle physiology and function. Here, we present applications for this technology to further our understanding of the molecular mechanisms underlying skeletal muscle adaptation in response to exercise.

Original language	English
Pages (from-to)	186-191
Number of pages	6
Journal	Exercise and sport sciences reviews
Volume	35
Issue number	4
Publication status	Published - Oct 2007

Keywords / Materials (for Non-textual outputs)

tissue engineering
exercise
fiber type
muscle development
muscle function
SKELETAL-MUSCLE
IN-VITRO
FIBER-TYPE
ELECTRICAL-STIMULATION
COLLAGEN GEL
RAT MUSCLES
MYOSIN
EXERCISE
ISOFORMS
INVITRO

Cite this

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title = "Engineered muscle: A tool for studying muscle physiology and function",

abstract = "Recent advances in skeletal muscle tissue engineering have resulted in an in vitro tissue model that can be used for studying the effects of genetic alterations, pharmacological interventions, and exercise on muscle physiology and function. Here, we present applications for this technology to further our understanding of the molecular mechanisms underlying skeletal muscle adaptation in response to exercise.",

keywords = "tissue engineering, exercise, fiber type, muscle development, muscle function, SKELETAL-MUSCLE, IN-VITRO, FIBER-TYPE, ELECTRICAL-STIMULATION, COLLAGEN GEL, RAT MUSCLES, MYOSIN, EXERCISE, ISOFORMS, INVITRO",

author = "Alastair Khodabukus and Paxton, {Jennifer Z.} and Kenneth Donnelly and Keith Baar",

year = "2007",

month = oct,

language = "English",

volume = "35",

pages = "186--191",

journal = "Exercise and sport sciences reviews",

issn = "0091-6331",

publisher = "Lippincott Williams and Wilkins",

number = "4",

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TY - JOUR

T1 - Engineered muscle

T2 - A tool for studying muscle physiology and function

AU - Khodabukus, Alastair

AU - Paxton, Jennifer Z.

AU - Donnelly, Kenneth

AU - Baar, Keith

PY - 2007/10

Y1 - 2007/10

N2 - Recent advances in skeletal muscle tissue engineering have resulted in an in vitro tissue model that can be used for studying the effects of genetic alterations, pharmacological interventions, and exercise on muscle physiology and function. Here, we present applications for this technology to further our understanding of the molecular mechanisms underlying skeletal muscle adaptation in response to exercise.

AB - Recent advances in skeletal muscle tissue engineering have resulted in an in vitro tissue model that can be used for studying the effects of genetic alterations, pharmacological interventions, and exercise on muscle physiology and function. Here, we present applications for this technology to further our understanding of the molecular mechanisms underlying skeletal muscle adaptation in response to exercise.

KW - tissue engineering

KW - exercise

KW - fiber type

KW - muscle development

KW - muscle function

KW - SKELETAL-MUSCLE

KW - IN-VITRO

KW - FIBER-TYPE

KW - ELECTRICAL-STIMULATION

KW - COLLAGEN GEL

KW - RAT MUSCLES

KW - MYOSIN

KW - EXERCISE

KW - ISOFORMS

KW - INVITRO

M3 - Literature review

SN - 0091-6331

VL - 35

SP - 186

EP - 191

JO - Exercise and sport sciences reviews

JF - Exercise and sport sciences reviews

IS - 4

ER -

Engineered muscle: A tool for studying muscle physiology and function

Abstract

Keywords / Materials (for Non-textual outputs)

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