ENGINEERING PATHWAYS FOR TRANSFORMATIONS OF MORPHINE ALKALOIDS

N C BRUCE, C E FRENCH, A M HAILES, M T LONG, D A RATHBONE, Chris French

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Semisynthetic opiates provide some of the most potent analgesic compounds currently in clinical use, the majority of which are synthesized from the naturally occurring alkaloids morphine, codeine and thebaine. The use of recombinant DNA technology to engineer pathways for the biological synthesis of semisynthetic opiate drugs could offer significant advantages over existing chemical methods and may, ultimately, provide novel biosynthetic routes for the development of new therapeutics.

Original languageEnglish
Pages (from-to)200-205
Number of pages6
JournalTrends in biotechnology
Volume13
Issue number6
Publication statusPublished - Jun 1995

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