Engineering prokaryote synthetic Biology biosensors

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Prokaryotic whole cell biosensors are effective yet inexpensive, renewable and environmentally substitutes for many contemporary sensors and diagnostic devices. Unfortunately, many previously constructed prokaryotic biosensors are plagued by poor performances, which prohibit their use in real life applications. Biosafety concerns, promiscuous analyte detection, analyte insensitivity, low output dynamic range and high background expression are common issues. Engineering principles and strategies from the emerging field of synthetic biology offer unprecedented solutions. They accelerate new biosensor developments and improve biosensor behaviors. Addition of novel devices and modules from synthetic biology further augments functions beyond sensing and render them safer. Thanks to this, prokaryotic whole cell biosensors have enjoyed a renaissance in recent years, and they hold promises to address the increasing demand for marketable biosensors.
Original languageEnglish
Title of host publicationHandbook of Cell Biosensors
EditorsG. Thouand
Place of PublicationSwitzerland
PublisherSpringer Nature
Pages1-37
Number of pages37
ISBN (Electronic)978-3-319-47405-2
DOIs
Publication statusE-pub ahead of print - 6 Mar 2019

Keywords

  • Whole-cell biosensor
  • Synthetic biology
  • Prokaryotes
  • Response curve
  • Sensitivity
  • Selectivity
  • Dynamic range
  • Leakiness

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