Enhancers: five essential questions

Len A. Pennacchio; Wendy Bickmore; Ann Dean; Marcelo A. Nobrega; Gill Bejerano

doi:10.1038/nrg3458

Enhancers: five essential questions

Len A. Pennacchio, Wendy Bickmore, Ann Dean, Marcelo A. Nobrega^*, Gill Bejerano

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

Abstract

It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.

Original language	English
Pages (from-to)	288-295
Number of pages	8
Journal	Nature Reviews Genetics
Volume	14
Issue number	4
DOIs	https://doi.org/10.1038/nrg3458
Publication status	Published - Apr 2013

Keywords / Materials (for Non-textual outputs)

REGULATORY SEQUENCES
LONG-RANGE INTERACTION
PROMOTER
HUMAN GENOME
ELEMENTS
TRANSCRIPTIONAL ENHANCERS
GENE ACTIVATION
LOCUS-CONTROL REGION
EVOLUTION
HUMAN-CELLS

Access to Document

10.1038/nrg3458

The role of spatial nuclear organisation in genome function
Bickmore, W. (Principal Investigator)
1/04/12 → 31/03/18
Project: Research

Cite this

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title = "Enhancers: five essential questions",

abstract = "It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.",

keywords = "REGULATORY SEQUENCES, LONG-RANGE INTERACTION, PROMOTER, HUMAN GENOME, ELEMENTS, TRANSCRIPTIONAL ENHANCERS, GENE ACTIVATION, LOCUS-CONTROL REGION, EVOLUTION, HUMAN-CELLS",

author = "Pennacchio, {Len A.} and Wendy Bickmore and Ann Dean and Nobrega, {Marcelo A.} and Gill Bejerano",

year = "2013",

month = apr,

doi = "10.1038/nrg3458",

language = "English",

volume = "14",

pages = "288--295",

journal = "Nature Reviews Genetics",

issn = "1471-0056",

publisher = "Nature Publishing Group",

number = "4",

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TY - JOUR

T1 - Enhancers

T2 - five essential questions

AU - Pennacchio, Len A.

AU - Bickmore, Wendy

AU - Dean, Ann

AU - Nobrega, Marcelo A.

AU - Bejerano, Gill

PY - 2013/4

Y1 - 2013/4

N2 - It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.

AB - It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.

KW - REGULATORY SEQUENCES

KW - LONG-RANGE INTERACTION

KW - PROMOTER

KW - HUMAN GENOME

KW - ELEMENTS

KW - TRANSCRIPTIONAL ENHANCERS

KW - GENE ACTIVATION

KW - LOCUS-CONTROL REGION

KW - EVOLUTION

KW - HUMAN-CELLS

U2 - 10.1038/nrg3458

DO - 10.1038/nrg3458

M3 - Literature review

SN - 1471-0056

VL - 14

SP - 288

EP - 295

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

IS - 4

ER -

Enhancers: five essential questions

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

The role of spatial nuclear organisation in genome function

Cite this