Enhancers: five essential questions

Len A. Pennacchio, Wendy Bickmore, Ann Dean, Marcelo A. Nobrega*, Gill Bejerano

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.

Original languageEnglish
Pages (from-to)288-295
Number of pages8
JournalNature Reviews Genetics
Volume14
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords / Materials (for Non-textual outputs)

  • REGULATORY SEQUENCES
  • LONG-RANGE INTERACTION
  • PROMOTER
  • HUMAN GENOME
  • ELEMENTS
  • TRANSCRIPTIONAL ENHANCERS
  • GENE ACTIVATION
  • LOCUS-CONTROL REGION
  • EVOLUTION
  • HUMAN-CELLS

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