ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

ENIGMA Consortium; Paul M Thompson; Ole A Andreassen; Alejandro Arias-Vasquez; Carrie E Bearden; Premika S Boedhoe; Rachel M Brouwer; Randy L Buckner; Jan K Buitelaar; Kazima B Bulayeva; Dara M Cannon; Ronald A Cohen; Patricia J Conrod; Anders M Dale; Ian J Deary; Emily L Dennis; Marcel A de Reus; Sylvane Desrivieres; Danai Dima; Gary Donohoe; Simon E Fisher; Jean-Paul Fouche; Clyde Francks; Sophia Frangou; Barbara Franke; Habib Ganjgahi; Hugh Garavan; David C Glahn; Hans J Grabe; Tulio Guadalupe; Boris A Gutman; Ryota Hashimoto; Derrek P Hibar; Dominic Holland; Martine Hoogman; Hilleke E Hulshoff Pol; Norbert Hosten; Neda Jahanshad; Sinead Kelly; Peter Kochunov; William S Kremen; Phil H Lee; Scott Mackey; Nicholas G Martin; Bernard Mazoyer; Colm McDonald; Sarah E Medland; Rajendra A Morey; Thomas E Nichols; Tomas Paus; Joanna M Wardlaw

doi:10.1016/j.neuroimage.2015.11.057

ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

ENIGMA Consortium, Paul M Thompson, Ole A Andreassen, Alejandro Arias-Vasquez, Carrie E Bearden, Premika S Boedhoe, Rachel M Brouwer, Randy L Buckner, Jan K Buitelaar, Kazima B Bulayeva, Dara M Cannon, Ronald A Cohen, Patricia J Conrod, Anders M Dale, Ian J Deary, Emily L Dennis, Marcel A de Reus, Sylvane Desrivieres, Danai Dima, Gary DonohoeSimon E Fisher, Jean-Paul Fouche, Clyde Francks, Sophia Frangou, Barbara Franke, Habib Ganjgahi, Hugh Garavan, David C Glahn, Hans J Grabe, Tulio Guadalupe, Boris A Gutman, Ryota Hashimoto, Derrek P Hibar, Dominic Holland, Martine Hoogman, Hilleke E Hulshoff Pol, Norbert Hosten, Neda Jahanshad, Sinead Kelly, Peter Kochunov, William S Kremen, Phil H Lee, Scott Mackey, Nicholas G Martin, Bernard Mazoyer, Colm McDonald, Sarah E Medland, Rajendra A Morey, Thomas E Nichols, Tomas Paus, Joanna M Wardlaw

Research output: Contribution to journal › Article › peer-review

Abstract

In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others(1), ENIGMA's genomic screens - now numbering over 30,000 MRI scans - have revealed at least 8 genetic loci that affect brain volumes. Downstream of gene findings, ENIGMA has revealed how these individual variants - and genetic variants in general - may affect both the brain and risk for a range of diseases. The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data. It is generating vast pools of normative data on brain measures - from tens of thousands of people - that may help detect deviations from normal development or aging in specific groups of subjects. We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.

Original language	English
Journal	NeuroImage
Early online date	4 Dec 2015
DOIs	https://doi.org/10.1016/j.neuroimage.2015.11.057
Publication status	E-pub ahead of print - 4 Dec 2015

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10.1016/j.neuroimage.2015.11.057

ENIGMA-and-the-individual
© 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 2.47 MBLicence: Creative Commons: Attribution (CC-BY)

Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III
Wardlaw, J. (Principal Investigator), Bastin, M. (Co-investigator) & Deary, I. (Co-investigator)
MRC
1/05/15 → 30/04/19
Project: Research
RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I. (Principal Investigator), Gale, C. (Co-investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), Maclullich, A. (Co-investigator), Porteous, D. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator), Wardlaw, J. (Co-investigator) & Okely, J. (Researcher)
1/09/13 → 31/08/19
Project: Research
Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I. (Principal Investigator), Bastin, M. (Co-investigator), Penke, L. (Co-investigator), Starr, J. (Co-investigator) & Wardlaw, J. (Co-investigator)
MRC
8/06/11 → 7/03/15
Project: Research

Cite this

ENIGMA Consortium, Thompson, P. M., Andreassen, O. A., Arias-Vasquez, A., Bearden, C. E., Boedhoe, P. S., Brouwer, R. M., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cannon, D. M., Cohen, R. A., Conrod, P. J., Dale, A. M., Deary, I. J., Dennis, E. L., de Reus, M. A., Desrivieres, S., Dima, D., ... Wardlaw, J. M. (2015). ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide. NeuroImage. Advance online publication. https://doi.org/10.1016/j.neuroimage.2015.11.057

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title = "ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide",

abstract = "In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others(1), ENIGMA's genomic screens - now numbering over 30,000 MRI scans - have revealed at least 8 genetic loci that affect brain volumes. Downstream of gene findings, ENIGMA has revealed how these individual variants - and genetic variants in general - may affect both the brain and risk for a range of diseases. The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data. It is generating vast pools of normative data on brain measures - from tens of thousands of people - that may help detect deviations from normal development or aging in specific groups of subjects. We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.",

author = "{ENIGMA Consortium} and Thompson, {Paul M} and Andreassen, {Ole A} and Alejandro Arias-Vasquez and Bearden, {Carrie E} and Boedhoe, {Premika S} and Brouwer, {Rachel M} and Buckner, {Randy L} and Buitelaar, {Jan K} and Bulayeva, {Kazima B} and Cannon, {Dara M} and Cohen, {Ronald A} and Conrod, {Patricia J} and Dale, {Anders M} and Deary, {Ian J} and Dennis, {Emily L} and {de Reus}, {Marcel A} and Sylvane Desrivieres and Danai Dima and Gary Donohoe and Fisher, {Simon E} and Jean-Paul Fouche and Clyde Francks and Sophia Frangou and Barbara Franke and Habib Ganjgahi and Hugh Garavan and Glahn, {David C} and Grabe, {Hans J} and Tulio Guadalupe and Gutman, {Boris A} and Ryota Hashimoto and Hibar, {Derrek P} and Dominic Holland and Martine Hoogman and Pol, {Hilleke E Hulshoff} and Norbert Hosten and Neda Jahanshad and Sinead Kelly and Peter Kochunov and Kremen, {William S} and Lee, {Phil H} and Scott Mackey and Martin, {Nicholas G} and Bernard Mazoyer and Colm McDonald and Medland, {Sarah E} and Morey, {Rajendra A} and Nichols, {Thomas E} and Tomas Paus and Wardlaw, {Joanna M}",

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month = dec,

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doi = "10.1016/j.neuroimage.2015.11.057",

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ENIGMA Consortium, Thompson, PM, Andreassen, OA, Arias-Vasquez, A, Bearden, CE, Boedhoe, PS, Brouwer, RM, Buckner, RL, Buitelaar, JK, Bulayeva, KB, Cannon, DM, Cohen, RA, Conrod, PJ, Dale, AM, Deary, IJ, Dennis, EL, de Reus, MA, Desrivieres, S, Dima, D, Donohoe, G, Fisher, SE, Fouche, J-P, Francks, C, Frangou, S, Franke, B, Ganjgahi, H, Garavan, H, Glahn, DC, Grabe, HJ, Guadalupe, T, Gutman, BA, Hashimoto, R, Hibar, DP, Holland, D, Hoogman, M, Pol, HEH, Hosten, N, Jahanshad, N, Kelly, S, Kochunov, P, Kremen, WS, Lee, PH, Mackey, S, Martin, NG, Mazoyer, B, McDonald, C, Medland, SE, Morey, RA, Nichols, TE, Paus, T & Wardlaw, JM 2015, 'ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide', NeuroImage. https://doi.org/10.1016/j.neuroimage.2015.11.057

TY - JOUR

T1 - ENIGMA and the individual

T2 - Predicting factors that affect the brain in 35 countries worldwide

AU - ENIGMA Consortium

AU - Thompson, Paul M

AU - Andreassen, Ole A

AU - Arias-Vasquez, Alejandro

AU - Bearden, Carrie E

AU - Boedhoe, Premika S

AU - Brouwer, Rachel M

AU - Buckner, Randy L

AU - Buitelaar, Jan K

AU - Bulayeva, Kazima B

AU - Cannon, Dara M

AU - Cohen, Ronald A

AU - Conrod, Patricia J

AU - Dale, Anders M

AU - Deary, Ian J

AU - Dennis, Emily L

AU - de Reus, Marcel A

AU - Desrivieres, Sylvane

AU - Dima, Danai

AU - Donohoe, Gary

AU - Fisher, Simon E

AU - Fouche, Jean-Paul

AU - Francks, Clyde

AU - Frangou, Sophia

AU - Franke, Barbara

AU - Ganjgahi, Habib

AU - Garavan, Hugh

AU - Glahn, David C

AU - Grabe, Hans J

AU - Guadalupe, Tulio

AU - Gutman, Boris A

AU - Hashimoto, Ryota

AU - Hibar, Derrek P

AU - Holland, Dominic

AU - Hoogman, Martine

AU - Pol, Hilleke E Hulshoff

AU - Hosten, Norbert

AU - Jahanshad, Neda

AU - Kelly, Sinead

AU - Kochunov, Peter

AU - Kremen, William S

AU - Lee, Phil H

AU - Mackey, Scott

AU - Martin, Nicholas G

AU - Mazoyer, Bernard

AU - McDonald, Colm

AU - Medland, Sarah E

AU - Morey, Rajendra A

AU - Nichols, Thomas E

AU - Paus, Tomas

AU - Wardlaw, Joanna M

PY - 2015/12/4

Y1 - 2015/12/4

N2 - In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others(1), ENIGMA's genomic screens - now numbering over 30,000 MRI scans - have revealed at least 8 genetic loci that affect brain volumes. Downstream of gene findings, ENIGMA has revealed how these individual variants - and genetic variants in general - may affect both the brain and risk for a range of diseases. The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data. It is generating vast pools of normative data on brain measures - from tens of thousands of people - that may help detect deviations from normal development or aging in specific groups of subjects. We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.

AB - In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others(1), ENIGMA's genomic screens - now numbering over 30,000 MRI scans - have revealed at least 8 genetic loci that affect brain volumes. Downstream of gene findings, ENIGMA has revealed how these individual variants - and genetic variants in general - may affect both the brain and risk for a range of diseases. The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data. It is generating vast pools of normative data on brain measures - from tens of thousands of people - that may help detect deviations from normal development or aging in specific groups of subjects. We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.

U2 - 10.1016/j.neuroimage.2015.11.057

DO - 10.1016/j.neuroimage.2015.11.057

M3 - Article

C2 - 26658930

SN - 1053-8119

JO - NeuroImage

JF - NeuroImage

ER -

ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

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Projects

Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II

Cite this