ENPP1 in the Regulation of Mineralization and Beyond

Fiona Roberts; Dongxing Zhu; Colin Farquharson; Vicky E Macrae

doi:10.1016/j.tibs.2019.01.010

ENPP1 in the Regulation of Mineralization and Beyond

Fiona Roberts, Dongxing Zhu, Colin Farquharson, Vicky E Macrae

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

ENPP1 is well known for its role in regulating skeletal and soft tissue mineralization. It primarily exerts its function through the generation of pyrophosphate, a key inhibitor of hydroxyapatite formation. Several previous studies have suggested that ENPP1 also contributes to a range of human diseases including diabetes, cancer, cardiovascular disease, and osteoarthritis. In this review, we summarize the pathological roles of ENPP1 in mineralization and these soft tissue disorders. We also discuss the underlying mechanisms through which ENPP1 exerts its pathological effects. A fuller understanding of the pathways through which ENPP1 acts may help to develop novel therapeutic strategies for these commonly diagnosed morbidities.

Original language	English
Journal	Trends in biochemical sciences
Early online date	21 Feb 2019
DOIs	https://doi.org/10.1016/j.tibs.2019.01.010
Publication status	E-pub ahead of print - 21 Feb 2019

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10.1016/j.tibs.2019.01.010

ENPP1 in the Regulation of Mineralization and BeyondAccepted author manuscript, 188 KBLicence: Creative Commons: Attribution No Derivatives (CC-BY-ND)

Control of development and reproductive traits
Burdon, T., Argyle, D., Ashworth, C., Beard, P., Brunton, P., Burt, D., Clinton, M., Dunn, I., Farquharson, C., Headon, D., Hocking, P., Hohenstein, P., Hume, D., Jackson, I., McColl, B., McGrew, M., McLachlan, G., Sang, H., Summers, K. & Whitelaw, B.
BBSRC
1/04/12 → 31/03/17
Project: Research

Cite this

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title = "ENPP1 in the Regulation of Mineralization and Beyond",

abstract = "ENPP1 is well known for its role in regulating skeletal and soft tissue mineralization. It primarily exerts its function through the generation of pyrophosphate, a key inhibitor of hydroxyapatite formation. Several previous studies have suggested that ENPP1 also contributes to a range of human diseases including diabetes, cancer, cardiovascular disease, and osteoarthritis. In this review, we summarize the pathological roles of ENPP1 in mineralization and these soft tissue disorders. We also discuss the underlying mechanisms through which ENPP1 exerts its pathological effects. A fuller understanding of the pathways through which ENPP1 acts may help to develop novel therapeutic strategies for these commonly diagnosed morbidities.",

author = "Fiona Roberts and Dongxing Zhu and Colin Farquharson and Macrae, {Vicky E}",

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language = "English",

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AU - Roberts, Fiona

AU - Zhu, Dongxing

AU - Farquharson, Colin

AU - Macrae, Vicky E

PY - 2019/2/21

Y1 - 2019/2/21

N2 - ENPP1 is well known for its role in regulating skeletal and soft tissue mineralization. It primarily exerts its function through the generation of pyrophosphate, a key inhibitor of hydroxyapatite formation. Several previous studies have suggested that ENPP1 also contributes to a range of human diseases including diabetes, cancer, cardiovascular disease, and osteoarthritis. In this review, we summarize the pathological roles of ENPP1 in mineralization and these soft tissue disorders. We also discuss the underlying mechanisms through which ENPP1 exerts its pathological effects. A fuller understanding of the pathways through which ENPP1 acts may help to develop novel therapeutic strategies for these commonly diagnosed morbidities.

AB - ENPP1 is well known for its role in regulating skeletal and soft tissue mineralization. It primarily exerts its function through the generation of pyrophosphate, a key inhibitor of hydroxyapatite formation. Several previous studies have suggested that ENPP1 also contributes to a range of human diseases including diabetes, cancer, cardiovascular disease, and osteoarthritis. In this review, we summarize the pathological roles of ENPP1 in mineralization and these soft tissue disorders. We also discuss the underlying mechanisms through which ENPP1 exerts its pathological effects. A fuller understanding of the pathways through which ENPP1 acts may help to develop novel therapeutic strategies for these commonly diagnosed morbidities.

U2 - 10.1016/j.tibs.2019.01.010

DO - 10.1016/j.tibs.2019.01.010

M3 - Review article

C2 - 30799235

SN - 0968-0004

JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

ER -

ENPP1 in the Regulation of Mineralization and Beyond

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Control of development and reproductive traits

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