Eosinophilic leukemia in 3 African pygmy hedgehogs (Atelerix albiventris) and validation of Luna stain

David Martínez-Jiménez, Bridget Garner, Sheryl Coutermarsh-Ott, Caitlin Burrell, Sabrina Clark, Mary Nabity, Josué Díaz-Delgado, Aline Rodrigues-Hoffmann, Karen Zaks, Laila Proença, Stephen Divers, Corey Saba, Paola Cazzini

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Neoplasia is usually encountered in the African pygmy hedgehog at a mean age of 3.5 years, and malignancy is common. Myelogenous leukemias are rarely reported in hedgehogs. We describe herein 3 cases of eosinophilic leukemia in adult, middle-aged (mean age 2.3 years) hedgehogs, for which prognosis appears grave. In one case, attempted treatment was unsuccessful, and in all 3 cases, the disease course was rapid and all died soon after diagnosis. Blood smear evaluation, along with complete blood count, was critical in making the diagnosis in all cases. Luna stain was validated and used to better visualize eosinophils in cytologic and histologic sections. Electron microscopy confirmed the presence of specific granules in hedgehog eosinophils.
Original languageEnglish
Article number1040638716687603
JournalJournal of Veterinary Diagnostic Investigation
Early online date24 Jan 2017
Publication statusE-pub ahead of print - 24 Jan 2017


  • African pygmy hedgehog
  • Atelerix albiventris
  • eosinophilic leukemia
  • Luna stain
  • myeloproliferative disease
  • neoplasia


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