Eosinophils—from cradle to grave: An EAACI task force paper on new molecular insights and clinical functions of eosinophils and the clinical effects of targeted eosinophil depletion

Milos Jesenak, Zuzana Diamant, Dagmar Simon, Ellen Tufvesson, Sven F. Seys, Manali Mukherjee, Paige Lacy, Susanne Vijverberg, Tomas Slisz, Anna Sediva, Hans‐uwe Simon, Ilja Striz, Jana Plevkova, Jurgen Schwarze, Radovan Kosturiak, Neil E. Alexis, Eva Untersmayr, Martina Koziar Vasakova, Edward Knol, Leo Koenderman

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be classified into primary (clonal) and secondary (reactive) disorders and idiopathic (hyper)eosinophilic syndromes. Depending on the biological specimen, the eosinophil count in different body compartments may serve as a biomarker reflecting the underlying pathophysiology and/or activity of distinct diseases and as a therapy-driving (predictive) and monitoring tool. Personalized selection of an appropriate therapeutic strategy directly or indirectly targeting the increased number and/or activity of eosinophils should be based on the understanding of eosinophil homeostasis including their interactions with other immune and non-immune cells within different body compartments. Hence, restoring as well as maintaining homeostasis within an individual's eosinophil pool is a goal of both specific and non-specific eosinophil-targeting therapies. Despite the overall favourable safety profile of the currently available anti-eosinophil biologics, the effect of eosinophil depletion should be monitored from the perspective of possible unwanted consequences.
Original languageEnglish
Pages (from-to)3077-3102
JournalAllergy
Volume78
Issue number12
Early online date13 Sept 2023
DOIs
Publication statusE-pub ahead of print - 13 Sept 2023

Keywords / Materials (for Non-textual outputs)

  • COVID-19
  • allergic diseases
  • biologics
  • biomarker
  • eosinophils
  • non-allergic diseases

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