Epidemiology and risk factors for resistance to treatment of Kawasaki disease in Cyprus

Maria G Koliou, Athina Aristidou, Stella Mazeri, Elena Georgiou, Maria Agathocleous, Marianna Kousparou, Avraam Elia, Antonis Jossif

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Kawasaki disease (KD) is one of the most common vasculitides of early childhood. There are no previous studies on KD in Cyprus. The aim of this study was to evaluate the epidemiology of KD in Cyprus, risk factors for resistance to treatment and the development of cardiac complications. This is a retrospective multicenter study of pediatric patients with KD hospitalized between January 2000 and-December 2019. The data were collected from medical records. A total of 136 patients with KD were included in the study. 83% of patients were < 5 years of age and 10% were < 6 months. Thirty patients (22%) developed coronary artery lesions. Serum sodium ≤ 133 mmol/L, albumin ≤ 3.2 g/dl, ALT ≥ 80 U/L and neutrophils percentage ≥ 80% at diagnosis, were identified as risk factors for resistance to IVIG. Clinical and epidemiological characteristics of KD in Cyprus population were similar to those reported in the literature. Although the majority of cases received appropriate treatment in time, cardiac complications still occurred.

Original languageEnglish
Article number352
Pages (from-to)1-8
JournalScientific Reports
Issue number1
Early online date7 Jan 2023
Publication statusPublished - Dec 2023

Keywords / Materials (for Non-textual outputs)

  • Child
  • Humans
  • Child, Preschool
  • Infant
  • Mucocutaneous Lymph Node Syndrome/drug therapy
  • Immunoglobulins, Intravenous/therapeutic use
  • Cyprus/epidemiology
  • Retrospective Studies
  • Risk Factors
  • Heart Diseases/complications


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