Projects per year
Abstract / Description of output
There are substantial limitations in our understanding of the distribution of antibiotic resistance (AMR) in humans and livestock in developing countries. Here, we present the results of an epidemiological study examining patterns of AMR in Escherichia coli isolates circulating in sympatric human (n=321) and livestock (n=633) samples from 99 households across Nairobi, Kenya. E. coli isolates were tested for susceptibility to 13 antimicrobial drugs representing 9 antibiotic classes. We detected high rates of AMR, with 47.6% and 21.1% of isolates displaying resistance to ≥ 3 and ≥5 antibiotic classes respectively. Human isolates showed higher levels of resistance to sulfonamides, trimethoprim, aminoglycosides and penicillins compared to livestock (p<0.01), while poultry isolates were more resistant to tetracyclines (p=0.01) compared to humans. The most common co-resistant phenotype observed was to tetracyclines, streptomycin and trimethoprim (30.5%). At the household level, AMR carriage in humans was associated with human density (p<0.01) and the presence of livestock manure (p=0.03), but livestock keeping on its own had no influence on human AMR carriage (p>0.05). Our findings revealed a high prevalence of AMR E. coli circulating in healthy humans and livestock in Nairobi, with no evidence to suggest that keeping livestock, when treated as a single risk factor significantly contributed to the burden of AMR in humans, although the presence of livestock waste was significant. These results provide an understanding of the broader epidemiology of AMR in complex, and interconnected urban environments.
Original language | English |
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Pages (from-to) | 531-537 |
Journal | International journal of antimicrobial agents |
Volume | 54 |
Issue number | 5 |
Early online date | 19 Aug 2019 |
DOIs | |
Publication status | E-pub ahead of print - 19 Aug 2019 |
Keywords / Materials (for Non-textual outputs)
- antibiotic resistance
- AMR
- Escherichia coli
- one health
- surveillance
Fingerprint
Dive into the research topics of 'Epidemiology of antimicrobial resistant Escherichia coli carriage in sympatric humans and livestock in a rapidly urbanising city'. Together they form a unique fingerprint.Projects
- 1 Finished
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Epidemiology, Ecology and Socio-Economics of Disease Emergence in Nairobi
Fevre, E. & Woolhouse, M.
1/02/12 → 31/07/13
Project: Research
Profiles
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Bram van Bunnik
- Royal (Dick) School of Veterinary Studies - Core Scientist in Quantitative Predictive Epidemiology
Person: Academic: Research Active (Research Assistant)