Epigenetic gene promoter methylation at birth is associated with child's later adiposity

Keith M Godfrey, Allan Sheppard, Peter D Gluckman, Karen A Lillycrop, Graham C Burdge, Cameron McLean, Joanne Rodford, Joanne L Slater-Jefferies, Emma Garratt, Sarah R Crozier, B Starling Emerald, Catharine R. Gale, Hazel M Inskip, Cyrus Cooper, Mark A Hanson

Research output: Contribution to journalArticlepeer-review

Abstract

Fixed genomic variation explains only a small proportion of the risk of adiposity. In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans.
Original languageEnglish
Pages (from-to)1528-34
Number of pages7
JournalDiabetes
Volume60
Issue number5
DOIs
Publication statusPublished - 2011

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